Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.

Inclusion criteria Part A

• Patient was ≥18 and ≤55 years old at time of screening.
• Patient had a body mass index (BMI) 50% (Note: prior diagnostic arthroscopy with debridement and lavage, 5 cigarettes/day). Urine cotinine levels will be measured during screening for all patients. Regular smokers will be defined as any patient who reports tobacco use of > 5 cigarettes/day and/or who has a urine cotinine ≥ 500 ng/mL.
• Patient had radiologically apparent degenerative joint disease in the target knee as determined by Kellgren and Lawrence grade ≥2 based on X-ray evaluation performed within 9 months from screening.
• Patient had patellofemoral dysplasia Dejour Grade B-D based on X-ray evaluation performed within 9 months from screening
• Patient had malalignment (valgus- or varus-deformity) in the target knee ≥ 5° based on X-ray evaluation performed within 9 months from screening. In suspected cases, the mechanical axis must be established radiographically through complete leg imaging during standing and in postero-anterior (PA) projection.

Exclusion Criteria Part B only

• Regular smokers (> 10 cigarettes/day).
• Clinical signs of inflammation (i.e., redness) in the target knee.
• History of knee replacement (unilateral or total) in either knee.
• Presence of severe hip OA conditioning lower limb function according to PI's evaluation.
• Nephrotic syndrome and/or significant proteinuria
• History of coagulopathy or medical condition requiring anticoagulation which would preclude knee injection
• Patient had malalignment (valgus- or varus-deformity) in the target knee ≥ 7.5° based on X-ray evaluation. In suspected cases, the mechanical axis must be established radiographically through complete leg imaging during standing and in postero-anterior (PA) projection.