N/A
N=60
Predictors and Consequences of Combustible Cigarette Smokers' Switch to Standardized Research E-Cigarettes
Tobacco Use
Bottom Line
View on ClinicalTrials.gov: NCT03277495 ↗Enrolled (actual)
60
Serious AEs
5.0%
Results posted
Feb 2026
Primary outcome: Primary: Combustible Cigarette Use — 3.79; 3.64 Number of cigarettes smoked per day
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Brief behavioral counseling (Behavioral)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- University of Illinois at Chicago
- Primary completion
- Aug 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Combustible Cigarette Use |
3.79; 3.64 | — |
| SECONDARY Abstinence |
6; 8 | — |
| SECONDARY Number of Cigarettes Smoked |
7.73; 5.93 | — |
Summary
The primary goal of this study is to examine whether cigarette smokers can reduce their use of conventional, combustible cigarettes by switching to a Standardized Research E-Cigarette (SREC); whether participants can maintain these reductions and use of SRECs over a 12-week period; and whether there are changes in subjective and objective measures of health, appeal and acceptability of the products used during this time frame.
Eligibility Criteria
Inclusion Criteria
- men and women 21 years of age or older;
- daily smoking rate of 3 cigarettes/day or greater for at least one year;
- interested in reducing cigarette use;
- willing to try e-cigarettes;
- able to attend in-person assessments over the next 5 months;
- English speaking; and
- breath CO of 3ppm or greater (assessed at baseline visit). Women who are of child-bearing age cannot be pregnant and must agree to use an approved form of birth control during the study.
Exclusion Criteria
- current use of any smoking cessation medication or participation in a smoking cessation program or study;
- current daily ENDS user;
- pregnancy if female; and
- no two members of the same household may participate in this study.
Data sourced from ClinicalTrials.gov (NCT03277495). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.