N/A
Completed N=29
Feasibility of High Intensity Interval Training in Knee Osteoarthritis
Source: ClinicalTrials.gov NCT03281668 ↗Enrolled (actual)
29
Serious AEs
0.0%
Results posted
Nov 2019
Primary outcomePrimary: Percent of Potential Participants Screened for the Study Who Are Enrolled — 19.3 percentage of participants
Summary
The focus of this pilot study is to evaluate the feasibility of utilizing an evidenced-based high intensity interval training program (HIIT) to improve physical function in patients with knee osteoarthritis (OA).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percent of Potential Participants Screened for the Study Who Are Enrolled |
19.3 | — |
| PRIMARY Percentage of Enrolled Participants Retained at the End of the Study |
72.4 | — |
| SECONDARY Average Number of Training Sessions Completed Per Week |
1.9 | — |
| SECONDARY Total Number of Training Sessions Completed |
19.4 | — |
| SECONDARY Total Number of Training Weeks Completed |
11.4 | — |
| SECONDARY Change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Total Score From Baseline to 12 Weeks |
-9.2 | — |
| SECONDARY Change in WOMAC Pain Subscale From Baseline to 12 Weeks |
-1.7 | — |
| SECONDARY Change in WOMAC Function Subscale From Baseline to 12 Weeks |
-6.3 | — |
| SECONDARY Change in 20m Fast Paced Walk Test |
-1.13 | — |
| SECONDARY Change in Number of Chair Stand Repetitions Completed |
2.6 | — |
| SECONDARY Change in Stair Climb Test |
-1.42 | — |
| SECONDARY Change in Timed Up and Go |
-0.58 | — |
| SECONDARY Change in Feet Together Stand |
0.00 | — |
| SECONDARY Change in Semi-tandem Stand |
0.52 | — |
| SECONDARY Change in Tandem Stand |
0.39 | — |
| SECONDARY Change in One Leg Stand |
3.41 | — |
| SECONDARY Change in Cardiorespiratory Fitness |
0.14 | — |
| SECONDARY Change in Whole Body Fat Mass |
-0.28 | — |
| SECONDARY Change in Lean Body Mass |
-0.12 | — |
| SECONDARY Change in Visceral Fat |
-0.19 | — |
| SECONDARY Change in Knee Strength |
3.34; -0.84; 9.99; 9.86 | — |
Eligibility Criteria
Inclusion Criteria
- between the ages of 40 and 75 years old
- body mass index of 18.5-50 kg/m²
- exhibits symptomatic knee OA, defined as a diagnosis of knee OA, as identified from University of North Carolina electronic medical records, and current knee symptoms in at least one knee, having a minimum score of 6 out of 20 on the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) pain subscale.
Exclusion Criteria
- individuals diagnosed with a cardiovascular condition restricting exercise
- individuals currently meeting Department of Health and Human Services Guidelines for physical activity (≥ 150 minutes per week
- individuals currently doing HIIT
- individuals currently participating in physical therapy for knee OA
- individuals currently participating in another OA intervention study
- received a corticosteroid or hyaluronic acid intra-articular injection in the knee during the previous 3 weeks or scheduled for during the intervention
- diagnosis of gout in the knee
- diagnosis of rheumatoid arthritis
- diagnosis of fibromyalgia
- other systemic rheumatic disease
- severe dementia or other memory loss
- active diagnosis of psychosis or uncontrolled substance abuse disorder
- hospitalization for a stroke, heart attack, or heart failure, or had surgery for blocked arteries in the past 3 months
- total joint replacement knee surgery, other knee surgery, meniscus tear, or anterior cruciate ligament (ACL) tear in the past 6 months
- on a waiting list for total joint replacement
- severely impaired hearing or speech
- pregnant or planning to become pregnant while enrolled in the study
- inability to speak English
- serious or terminal illness as indicated by referral to hospice or palliative care
- nursing home residence
- inability to ride a stationary bike
- any other health problems that would prohibit safe participation in the study
- EKG results EKG suggesting the individual would not be able to safely participate in this study
Data sourced from ClinicalTrials.gov (NCT03281668). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.