Phase 4
Completed N=55
Randomized Controlled Trial for Exparel Hip Fracture
Source: ClinicalTrials.gov NCT03289858 ↗Enrolled (actual)
55
Serious AEs
1.8%
Results posted
Feb 2020
Primary outcomePrimary: Opiate Requirements — 52.5; 65.39 Morphine mEq
◆ Published Evidence
Established
91citations · ~15 / year
Peripheral nerve blocks for hip fractures in adults.
Summary
This is a prospective, randomized study looking at the effect that a long-acting local anesthetic has on pain control in patients having surgery for hip fractures. The investigators are conducting the study to see if that reduces the amount of pain medicine needed after surgery, and if it reduces other medical complications after surgery.
Linked Publications
-
Peripheral nerve blocks for hip fractures in adults.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Opiate Requirements |
52.5; 65.39 | — |
Eligibility Criteria
Inclusion Criteria
- Age 55 or older
- Sustaining either an OTA/AO type 31A or 31B fracture undergoing ORIF or hemiarthroplasty
- Able to consent
- Isolated injury
Exclusion Criteria
- OTA/AO 31B1 (Impacted/slightly displaced)
- Baseline dementia or cognitive deficit
- Inability to consent
- Chronic Opioid use
- End stage liver disease with Model for End-Stage Liver Disease (MELD) greater than 20.
- End stage renal disease as defined by patients requiring hemodialysis at least twice weekly
- Polytrauma, defined as: concurrent upper or lower extremity fracture, pelvis fracture, spine fracture, rib fractures, or facial fractures, Blunt chest or abdominal trauma resulting in diagnosed organ injury, Head trauma resulting in intracranial bleed or diagnosed concussion
- Allergy to amide-type local anesthetics
- Prisoners (unlikely to be accessible for follow-up)
Data sourced from ClinicalTrials.gov (NCT03289858) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.