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Home › Conditions › Hip Fracture

Hip Fracture

Subtypes of Hip Fracture

Femoral Neck Fracture 3 Proximal femoral fracture 2

20 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hip Fracture

31 trials tracked for Hip Fracture: 10 in phase 3 or 4 and 4 with published results. The most-cited published study has 95 citations.

31Trials tracked
10Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 7 Phase 3 3 Phase 2 5 Other / NA 16
  1. Phase 4 Randomized Controlled Trial for Exparel Hip Fracture Completed · 95 cited
  2. Phase 3 Starting a Testosterone and Exercise Program After Hip Injury Completed · 78 cited
  3. Phase 4 Comparative Study Between Levobupivacaine and Ropivacaine in the Hip Fractures of the Elderly Completed · 6 cited
  4. Phase 4 Comparison of the Efficiency of Femur Nerve Block and Intravenous Analgesia Treatment in Hip Fracture Patients Completed · 2 cited
  5. Phase 4 Does Tranexamic Acid Reduce the Need for Blood Transfusions in Patients Undergoing Hip Fracture Surgery? Completed
  6. Phase 4 Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients Completed
Show 25 more trials
  1. Phase 4 Does Omeprazole Decrease Intestinal Calcium Absorption? Completed
  2. Phase 4 A Randomised, Controlled Comparison of Vitamin D Strategies is Acute Hip Fracture Patients Completed
  3. Phase 3 Exercise and Testosterone Therapy in Elderly Men With Physical Frailty Completed
  4. Phase 3 Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population Completed
  5. Phase 2 Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery Completed
  6. Phase 2 Acute Hip Fracture Study in Patients 65 Years or Greater Completed
  7. Phase 2 Does Early Administration of Tranexamic Acid Reduce Blood Loss and Perioperative Transfusion Requirement Completed
  8. Phase 2 Ultrasound-guided Femoral Nerve Blocks in Elderly Patients With Hip Fractures Completed
  9. Phase 2 Pilot Study of Atorvastatin for Orthopedic Surgery Patients Completed
  10. N/A Polyurethane Foam on the Sacrum for Prevention Completed
  11. N/A Surgical Treatment of Hip Fractures Under Peripheral Regional Anesthesia Completed
  12. N/A Variations in Anesthesia Care for Hip Fracture Surgery Completed
  13. N/A Optimizing Cerebral Autoregulation During Surgery Completed
  14. N/A Post-Operative Delirium in Elderly Surgical Patients Completed
  15. N/A Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures Completed
  16. N/A Role of Vacuum Assisted Closure (VAC) Device in Postoperative Management of Pelvic and Acetabular Fractures Completed
  17. N/A Mobilizing Evidence Into Action to Improve Outcomes of Vulnerable Seniors Completed
  18. N/A Validity and Reliability of Thai Version of Barthel Index for Hip Fracture Patients Completed
  19. N/A Vitamin D Levels in Frail Elderly Patients With a Hip Fracture Completed
  20. N/A Observational Clinical Study on Elderly Patients With Fracture of the Proximal Femur Treated With the Chimaera Nail Completed
  21. N/A Women's Health Initiative Strong and Healthy Study Completed
  22. N/A Effects of Bisphosphonates and Nutritional Supplementation After a Hip Fracture Completed
  23. N/A Regional Versus General Anesthesia for Promoting Independence After Hip Fracture Completed
  24. N/A A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia Completed
  25. N/A Body Weight Supported Treadmill Training Following Hip Fracture Completed

Showing the 31 most-cited and recently-updated of 31 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Hip Fracture: what the trials found

For pain management after hip fracture surgery, local anesthetics such as Exparel 4 and levobupivacaine 5 have been studied, as well as intravenous fentanyl 6 and intravenous morphine 8. A phase 4 trial of IV morphine showed significant pain reduction at 30 minutes (p<.0001) and 60 minutes (p<.05) compared to comparators 8. Another trial reported a pain score change of 4 vs 2 with IV fentanyl 6.

Tranexamic acid (TXA) has been evaluated in multiple trials for reducing transfusion needs. One phase 4 trial found a lower mean number of units transfused (1.8 vs 1.2) 7, while a phase 3 trial showed no significant difference in transfusion rates (p=0.966) 12. Mortality was not significantly different (p=0.75) 7. The evidence on TXA's effect on transfusion is mixed.

Testosterone therapy was assessed in two phase 3 trials. One trial found a significant increase in total lean body mass (p=0.01) but no significant change in muscle strength 13. Another trial showed no significant improvement in six-minute walk distance (p=0.853) or lean body mass (p=0.336) 11. Thus, evidence for testosterone's functional benefit is conflicting.

Vitamin D2 supplementation was studied in a phase 4 trial, which reported functional outcomes including Timed Up and Go test and Two Minute Walk Test at 3 months, but no p-values were provided for comparison 10.

Recent results — preliminary, needs further review

  • A phase 2 trial of VK5211 showed significant improvement in efficacy in hip fracture patients confirmed by DXA scan (p=0.0032) 1.
  • A large trial of physical activity (N=49331) found no significant reduction in cardiovascular events (p=0.49) but significant improvement in physical function score (p<0.001) 2.
  • A trial of Chimaera short nail with telescopic cephalic screws reported 0% needing second surgery and functional scores of 4.11, 3.14, 1.73 3.
  • A trial of blood pressure management according to cerebral autoregulation found no significant differences in mean arterial pressure outside limits (p=0.60), estimated blood loss (p=0.60), or myocardial infarction (p=1.0) 18.

For the clinician treating this condition

  • For pain control, IV morphine and fentanyl are effective options; local anesthetics like Exparel and levobupivacaine are also available.
  • Tranexamic acid may reduce transfusion needs in some patients, but evidence is mixed; no mortality benefit was observed.
  • Testosterone therapy may increase lean body mass but does not consistently improve functional outcomes.
  • Recent evidence suggests VK5211 may improve bone density, and physical activity can enhance physical function without reducing cardiovascular events.

AI synthesis of 13 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Multidimensional biomarkers of nutritional, inflammatory, and metabolic status identify risk in geriatric hip fracture patients
Nutrition & Obesity Medicine Meta-analysis
Multidimensional biomarkers of nutritional, inflammatory, and metabolic status identify risk in geriatric hip fracture patients Blood tests predict hip fracture surgery risks
This meta-analysis of 28,605 elderly patients with hip fractures identifies several multidimensional biomarkers associated with short-term a…
Simple blood tests may flag elderly hip fracture patients at higher risk for complications after surgery, a new analysis finds.
Frontiers Aug 23, 2026
Nutrition-related laboratory biomarkers provide risk stratification for geriatric patients with hip fractures
Nutrition & Obesity Medicine Sys. Review
Nutrition-related laboratory biomarkers provide risk stratification for geriatric patients with hip fractures Nutrition markers may help predict recovery after hip fractures
This narrative review synthesizes the role of nutrition-related laboratory indicators, such as serum albumin and prealbumin, in predicting o…
Up to 46% of elderly patients with hip fractures suffer from malnutrition, which can impact their recovery and long-term health outcomes.
Frontiers Aug 22, 2026
Specific muscle weaknesses following hip fractures correlate with persistent gait impairments and instability
Rheumatology Sys. Review
Specific muscle weaknesses following hip fractures correlate with persistent gait impairments and instability Muscle Weakness Linked to Walking Problems After Hip Fractures
This narrative review synthesizes evidence regarding the relationship between post-hip fracture muscle atrophy and functional mobility in ol…
Specific muscle weaknesses after hip fractures are linked to walking difficulties and instability, highlighting the need for targeted rehabi…
Frontiers Aug 5, 2026
Cemented hip stems reduce mortality and periprosthetic fractures in elderly femoral neck fracture patients
Orthopedics & Sports Medicine Meta-analysis
Cemented hip stems reduce mortality and periprosthetic fractures in elderly femoral neck fracture patients Cemented Fixation Reduces Mortality for Femoral Neck Fractures
A meta-analysis of randomized trials compared cemented versus uncemented femoral stem fixation in elderly patients with displaced femoral ne…
A meta-analysis of over 3,700 patients suggests that cemented hip implants may lower mortality and fracture risks after a broken femur.
Aug 3, 2026
Predictive models for postoperative infection risk in hip fractures show AUC of 0.699 to 0.946
Rheumatology Meta-analysis
Predictive models for postoperative infection risk in hip fractures show AUC of 0.699 to 0.946 Predictive Models Help Identify Risk of Infection After Hip Surgery
This meta-analysis of 17 articles covering 21 predictive models evaluated the performance of tools identifying postoperative infection risk …
New data shows that specific risk factors like diabetes and age can help predict if a patient will develop an infection after hip surgery.
Frontiers Jul 27, 2026
Preoperative tranexamic acid did not reduce transfusion rates in geriatric patients with hip fractures
Orthopedics & Sports Medicine RCT
Preoperative tranexamic acid did not reduce transfusion rates in geriatric patients with hip fractures Trial shows tranexamic acid does not reduce hip fracture transfusions
This randomized controlled trial of 283 geriatric patients with hip fractures found no significant difference in postoperative transfusion b…
A new trial of 283 patients found that the drug tranexamic acid did not reduce the need for blood transfusions after hip fracture surgery.
Jul 5, 2026
Ferroptosis and lipid metabolism dysregulation drive inflammatory responses in elderly patients with hip fractures
Genetics & Precision Medicine Sys. Review
Ferroptosis and lipid metabolism dysregulation drive inflammatory responses in elderly patients with hip fractures New Research Identifies Molecular Drivers in Hip Fracture Recovery
This systematic review synthesizes the role of ferroptosis, lipid metabolism, and genetic regulation in elderly patients with hip fractures.…
Researchers have identified how cell death and lipid metabolism impact recovery for elderly patients with hip fractures and bone tumors.
Frontiers Jun 20, 2026
Discharge planning services improve self-care capacity and functional recovery in patients with hip fractures
Orthopedics & Sports Medicine Meta-analysis
Discharge planning services improve self-care capacity and functional recovery in patients with hip fractures Discharge planning services help patients recover from hip fractures
This meta-analysis of randomized controlled trials involving 861 patients found that discharge planning services (DPS) significantly improve…
Specialized discharge planning can improve self-care, physical function, and lower complication rates for people recovering from a broken hi…
Jun 16, 2026
Postoperative delirium linked to greater cognitive decline one year after hip fracture repair in older adults
Orthopedics & Sports Medicine RCT
Postoperative delirium linked to greater cognitive decline one year after hip fracture repair in older adults Postoperative delirium linked to worse thinking one year after hip fracture repair
This secondary analysis of a randomized clinical trial examined older adults with hip fracture repair. Participants with postoperative delir…
Older adults with hip fractures who developed postoperative delirium showed greater cognitive decline one year later compared to those witho…
Jun 5, 2026
Systematic review and meta-analysis on radiographic hip morphometry and fracture patterns
Orthopedics & Sports Medicine Meta-analysis
Systematic review and meta-analysis on radiographic hip morphometry and fracture patterns Hip bone shape predicts fracture type in older patients
This systematic review with meta-analysis synthesized data from 4184 patients with unilateral proximal femoral fractures. It found specific …
Simple hip bone measurements from standard X-rays can help predict fracture patterns in elderly patients. This analysis of 4,184 cases shows…
May 22, 2026
Systematic review links slower Timed Up-and-Go test to higher fracture risk in older adults
Primary Care & Family Medicine Meta-analysis
Systematic review links slower Timed Up-and-Go test to higher fracture risk in older adults Slower movement test results linked to higher chance of breaking bones in older adults
This systematic review and meta-analysis examines the association between Timed Up-and-Go (TUG) test performance and fracture risk in older …
A large review found that older people who take longer to stand up and walk have a higher risk of hip and other bone breaks. This simple tes…
Frontiers May 11, 2026
Narrative review discusses postoperative care strategies for older adults with hip fracture and cognitive impairment
Primary Care & Family Medicine Sys. Review
Narrative review discusses postoperative care strategies for older adults with hip fracture and cognitive impairment New care plans help seniors with memory loss recover from broken hips
This narrative review examines postoperative care management strategies for older adults with hip fracture and cognitive impairment.
New care plans help seniors with memory loss recover from broken hips by reducing confusion and speeding up movement after surgery.
Frontiers Apr 29, 2026

Questions about Hip Fracture

What care strategies help older adults with hip fractures who also have memory problems?

For older adults with hip fracture and memory problems, key strategies include careful pain management, delirium prevention, early mobilization, and a team-based orthogeriatric approach.

Full answer →

All Hip Fracture Articles