Phase 4
Completed N=10
Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage
Cervical Incompetence
Source: ClinicalTrials.gov NCT03305575 ↗
Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Aug 2020
Primary outcomePrimary: Duration of Motor Block — 75; 99 minutes
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
This study aims to compare the effect of chloroprocaine vs. bupivacaine on duration of motor block and duration until meeting discharge criteria in patients undergoing cervical cerclage. The hypothesis is that chloroprocaine will result in faster resolution of motor block.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Duration of Motor Block |
75; 99 | — |
| SECONDARY Duration of Sensory Block |
127; 210 | — |
| SECONDARY Time to Ambulation |
110; 179 | — |
| SECONDARY Time to Micturation |
111; 233 | — |
Eligibility Criteria
Inclusion Criteria
- ASA classification II or III females
- Age: 18-45 years old
- BMI ≤ 50 kg/m2
- Singleton pregnancy
- Simple prophylactic cervical cerclage
- Planning neuraxial anesthesia
Exclusion Criteria
- Abdominal and complex cervical cerclage (e.g. bulging bag)
- Contraindication to neuraxial anesthesia
- Known hypersensitivity to chloroprocaine (a.k.a. Ester allergy), paraaminobenzoic acid (PABA) or bupivacaine (a.k.a. Amide allergy)
- Pseudocholinesterase deficiency
- Concomitant use with ergot-type oxytocic drugs
Data sourced from ClinicalTrials.gov (NCT03305575). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.