N/A N=271 Randomized Single-blind Treatment

Effect of Reducing Sedentary Behavior on Blood Pressure

Hypertension · Prehypertension

Bottom Line

View on ClinicalTrials.gov: NCT03307343 ↗

Enrolled (actual)

271

Serious AEs

2.9%

Results posted

Dec 2024

Primary outcome: Primary: Resting Systolic Blood Pressure — 129.5; 127.9; 124.3; 123.6 mm Hg

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Intervention (Behavioral)
Age: Adult, Older Adult · 21+ yrs
Sex: All
Sponsor: University of Pittsburgh
Primary completion: Nov 2022

Outcome Measures

Outcome	Result	p-value
PRIMARY Resting Systolic Blood Pressure	129.5; 127.9; 124.3; 123.6	—
SECONDARY Resting Diastolic Blood Pressure	82.7; 82.9; 79.7; 79.9	—
SECONDARY 24-Hour Systolic/Diastolic Ambulatory Blood Pressure	130.2; 129.5; 78.1; 78.4; 130.2; 129.7	—
SECONDARY Pulse Wave Velocity	8.22; 7.66; 9.09; 8.97; 8.29; 7.68	—
SECONDARY Plasma Renin Activity	-0.16; 0.07	—
SECONDARY Aldosterone	-0.52; 13.14	—

Summary

This is a 2-arm, 3-month randomized trial comparing a novel sedentary behavior intervention vs. control in working adults (n=271). The primary outcome is resting systolic blood pressure (SBP) at 3 months; secondary outcomes will be resting diastolic blood pressure (DBP), ambulatory blood pressure (ABP), and carotid-femoral pulse wave velocity (cfPWV). Also, best practice objective activity monitoring will be leveraged in the analysis of ABP to account for recent activity and posture and will inform adherence and dose-response relationships.We will also measure plasma renin activity and aldosterone as a potential mechanism of blood pressure reduction, and insulin and glucose as exploratory outcomes.

Eligibility Criteria

Inclusion Criteria

Age 21-65 years
SBP 120-159 mmHg or DBP of 80-99
Inactive (Engages in less than 150 min/wk of moderate + 2 x vigorous intensity physical activity)
Currently perform deskwork for ≥ 20 hr/week at a desk compatible with the sit-stand attachment
Employment within an approximate 25-mile radius of the University of Pittsburgh
Stable employment (≥ 3 months in current job, plan to be in current job for the next 3 months)
Supervisor approval to join the intervention
Possession of a cellular phone able to receive text messages

Exclusion Criteria

SBP ≥ 160 mmHg, DBP ≥ 100 mmHg
Use of antihypertensive or glucose controlling medication
Comorbid condition that would limit ability to reduce sedentary behavior (e.g. musculoskeletal condition, current chemotherapy)
History of ischemic heart disease, chronic heart failure, stroke, or chronic kidney disease
Unable to obtain consent from primary care provider or physician to participate
Current use of sit-stand/standing desk, sedentary behavior prompting device, enrollment in a weight loss or exercise study or program, recent ( 1 week) during the study period

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03307343). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.