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Home › Conditions › Prehypertension

Prehypertension

Part of Hypertension

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Prehypertension

9 trials tracked for Prehypertension: 5 in phase 3 or 4 and 3 with published results. The most-cited published study has 26 citations.

9Trials tracked
5Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 5 Phase 2 1 Other / NA 3
  1. Phase 4 Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure Completed · 26 cited
  2. Phase 4 Nebivolol and the Endothelin (ET)-1 System Completed · 23 cited
  3. Phase 4 Nebivolol and Endothelial Regulation of Fibrinolysis (NERF) Completed · 9 cited
  4. Phase 4 Effect of Dapagliflozin on Blood Pressure Variability in Prediabetes and Prehypertension Completed
  5. Phase 4 Angiotensin II Blockade and Inflammation in Obesity Completed
  6. Phase 2 A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure Completed
Show 3 more trials
  1. N/A Effect of Reducing Sedentary Behavior on Blood Pressure Completed
  2. N/A The Effects of a Jump Rope Exercise Program on Vascular Health, Inflammatory Markers in Prehypertensive Adolescent Girls Completed
  3. N/A Clinical Trial of H2-BP Electronic Sphygmomanometer Completed

Showing the 9 most-cited and recently-updated of 9 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Prehypertension: what the trials found

Clinical investigations into prehypertension have evaluated several pharmacological agents, including Febuxostat 1 and Olmesartan medoxomil 5.

Nebivolol was evaluated for its impact on vascular function. Research indicates that Nebivolol therapy over 12 weeks resulted in significant changes in endothelial t-PA release in response to Bradykinin (BDK) and BDK+Vitamin C 3. Additionally, studies assessed the percent change in Forearm Blood Flow (FBF) in response to BQ-123 with or without BQ-788 2.

Dapagliflozin was evaluated for its effect on blood pressure over 12 weeks. Results showed no statistically significant differences in 24-hour Systolic Blood Pressure (p=0.755), 24-hour Diastolic Blood Pressure (p=0.752), or Daytime Systolic Blood Pressure (p=0.814) 4.

Recent results — preliminary, needs further review

  • B244 showed results in a Phase 2 trial, but findings are not yet corroborated 6.
  • H2-BP was evaluated in a study of 141 participants, but findings are not yet corroborated 7.
  • An intervention study involving 271 participants is currently uncorroborated 8.
  • A jump rope exercise intervention was studied in a group of 40, but results are not yet corroborated 9.

For the clinician treating this condition

  • Nebivolol has been shown to influence endothelial t-PA release following 12 weeks of therapy 3.
  • Dapagliflozin did not produce statistically significant changes in systolic or diastolic blood pressure over a 12-week period 4.

AI synthesis of 9 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Network meta-analysis shows exercise modalities reduce blood pressure in adults with prehypertension or hypertension
Physical Medicine & Rehab Meta-analysis
Network meta-analysis shows exercise modalities reduce blood pressure in adults with prehypertension or hypertension Combined training and high-intensity interval training lower blood pressure in adults with prehypertension and hypertension
This network meta-analysis synthesizes data from 105 randomized controlled trials involving adults with prehypertension and established hype…
Combined training and high-intensity interval training significantly lower blood pressure in adults with prehypertension or hypertension, of…
May 19, 2026