N/A
Completed N=31
Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking
Source: ClinicalTrials.gov NCT03311646 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Jan 2020
Primary outcomePrimary: Breath Sample (Expired Carbon Monoxide) — 18.77; 31.07; 25.38; 30.49 parts per million — p=0.92
Summary
Smoking is the leading cause of preventable death in the United States. An FDA-mandated reduction in the nicotine content of cigarettes might reduce the health burden of tobacco by reducing the prevalence of smoking. The proposed project will test the impact of nicotine reduction on smoking behavior and smoke exposure in a setting where participants are restricted from using their usual brand cigarettes.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Breath Sample (Expired Carbon Monoxide) |
18.77; 31.07; 25.38; 30.49; 36.72; 35.66 | 0.92 |
| PRIMARY Average Cigarettes Smoked Per Day |
19.13; 22.38; 20.13; 20.69 | 0.15 |
| SECONDARY Minnesota Nicotine Withdrawal Scale |
23.94; 24.19; 23.69; 25.00 | <0.001 sig |
| SECONDARY Questionnaire of Smoking Urges |
19.94; 21.31; 20.00; 18.94 | 0.84 |
Eligibility Criteria
Inclusion Criteria
- male or female participants who are least 18 years old and smoke daily
- willing to stay in a hotel for two four-night stays during the prearranged dates
Exclusion Criteria
- unwilling to use research cigarettes as part of the trial
- pregnant, trying to become pregnant, or breastfeeding
- additional smoking and health criteria determined at screening
Data sourced from ClinicalTrials.gov (NCT03311646). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.