N/A
N=46
the Effect of Dopamine on Mechanical Ventilation Induced Lung Injury
Acute Lung Injury
Bottom Line
View on ClinicalTrials.gov: NCT03317431 ↗Enrolled (actual)
46
Serious AEs
—
Results posted
Oct 2018
Primary outcome: Primary: Correlation Coefficient (r) Between Duration of Mechanical Ventilation and DRD1 Expression — -0.555 pearson Correlation Coefficient — p=<0.01
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- mechanical ventilation (Other)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Primary completion
- Oct 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Correlation Coefficient (r) Between Duration of Mechanical Ventilation and DRD1 Expression |
-0.555 | <0.01 sig |
| SECONDARY Correlation Coefficient (r) Between Duration of Mechanical Ventilation and DRD2 Expression |
0.094 | >0.01 |
| SECONDARY the Expression of TH in Lung Tissues |
-0.047 | >0.01 |
| SECONDARY the Expression of DDC in Lung Tissues |
-0.012 | >0.01 |
| SECONDARY the Expression of Ac-a-tubulin in Lung Tissues |
-0.465 | <0.01 sig |
Summary
Dopamine(DA) is a common neurotransmitter that has been known to regulate behavior, movement, cardiovascular，endocrine and gastrointestinal functions, but also functions as an important molecule engaging in the immune systems to possess anti-inflammatory effects. However, its role in ventilator-induced lung injury (VILI) is still unclear. Herein, this study aimed to investigate the therapeutic efficacy of dopamine on ventilation-induced lung endothelial barrier dysfunction and explore the possible underlying molecular mechanisms.
Eligibility Criteria
Inclusion Criteria
- Patients inclusion criteria: undergo elective lobectomy with general anesthesia and mechanical ventilation; classified as physical status I to III according to the American Society of Anesthesiologists Physical Status Classification System; Written informed consent is approved.
Exclusion Criteria
- Distant metastases: recent anaesthetics or mechanical ventilation treatment；children；women during pregnancy or lactation; being involved in other clinical subjects.
Data sourced from ClinicalTrials.gov (NCT03317431). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.