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Home › Conditions › Acute Lung Injury

Acute Lung Injury

Part of Acute Respiratory Distress Syndrome

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Acute Lung Injury

25 trials tracked for Acute Lung Injury: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 27 citations.

25Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 3 Phase 2 13 Phase 1 1 Other / NA 8
  1. Phase 3 Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure Completed · 27 cited
  2. Phase 3 CALIPSO: Calfactant for Acute Lung Injury in Pediatric Stem Cell Transplant and Oncology Patients Completed
  3. Phase 3 L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects Completed
  4. Phase 2 Ascorbic Acid (Vitamin C) Infusion in Human Sepsis Completed
  5. Phase 2 The Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury Completed
  6. Phase 2 Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury Completed
Show 19 more trials
  1. Phase 2 Hemodynamics and Extravascular Lung Water in Acute Lung Injury Completed
  2. Phase 2 SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI) Completed
  3. Phase 2 Safety, Tolerability and Preliminary Efficacy of FP-1201 in ALI and ARDS. Phase I/II Completed
  4. Phase 2 Citrulline in Severe Sepsis Completed
  5. Phase 2 Modulation of Lung Injury Complicating Lung Resection Completed
  6. Phase 2 Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant Completed
  7. Phase 2 Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury Completed
  8. Phase 2 Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure Completed
  9. Phase 2 A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI) Completed
  10. Phase 2 SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS Completed
  11. Phase 1 Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome Completed
  12. N/A Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins Completed
  13. N/A Extracardiac Complications After Cardiac Surgery Completed
  14. N/A Intensive Alveolar Recruitment Protocol After Cardiac Surgery Completed
  15. N/A The Role of Circulating Soluble CD74 in Acute Lung Injury Completed
  16. N/A Efficacy and Safety of a Lung Recruitment Protocol in Children With Acute Lung Injury Completed
  17. N/A Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress Completed
  18. N/A the Effect of Dopamine on Mechanical Ventilation Induced Lung Injury Completed
  19. N/A Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study Completed

Showing the 25 most-cited and recently-updated of 25 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Intravenous Recombinant Human Plasma Gelsolin Safety and Pharmacokinetics Evaluated in Phase 1 Trial of Healthy Volunteers
Drug Pipeline RCT
Intravenous Recombinant Human Plasma Gelsolin Safety and Pharmacokinetics Evaluated in Phase 1 Trial of Healthy Volunteers Can this new IV drug be safely given? Early results show mild effects
This Phase 1 randomized controlled trial evaluated the safety and pharmacokinetics of intravenous recombinant human plasma gelsolin in 32 he…
A new IV drug caused only mild side effects in healthy volunteers, but doctors must wait for more data before using it to treat sick patient…
medRxiv Apr 19, 2026
Review of preclinical EVs for sepsis-associated acute lung injury
Pulmonology & Critical Care Sys. Review
Review of preclinical EVs for sepsis-associated acute lung injury Lungs Heal Themselves Using Body’s Own Repair System
This narrative review examines extracellular vesicles (EVs) and EV-inspired biomimetic nanosystems as a potential therapeutic approach for…
Tiny cell bubbles calm deadly lung inflammation in sepsis, offering a new way to help the body fix its own lungs during severe infections.
Frontiers Apr 18, 2026
Systematic review examines miRNA-mediated neutrophil regulation for acute lung injury, asthma, fibrosis, and lung cancer
Allergy & Immunology Sys. Review
Systematic review examines miRNA-mediated neutrophil regulation for acute lung injury, asthma, fibrosis, and lung cancer Tiny Molecules in Your Blood May Control Lung Inflammation
This systematic review evaluated miRNA-mediated regulation of neutrophil dynamics as a potential therapeutic strategy for acute lung injury,…
Tiny molecules in your blood act as a switch that controls the immune cells causing lung damage in asthma, fibrosis, and cancer.
Frontiers Apr 14, 2026
Outbreak report summarizes patterns and characteristics of vaping-associated lung injury cases
Infectious Disease
Outbreak report summarizes patterns and characteristics of vaping-associated lung injury cases What did we learn from the vaping lung injury outbreak?
An observational outbreak report summarized patterns and characteristics of lung injury cases associated with e-cigarette use across multipl…
A 2019 wave of serious lung injuries swept across the United States, and all the cases had one thing in common: the people affected had used…
CDC Apr 6, 2026