Phase 4
Completed N=60
Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery?
Knee Osteoarthritis · Knee Rheumatism
Source: ClinicalTrials.gov NCT03326999 ↗
Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Aug 2020
Primary outcomePrimary: Morphine Equivalence Consumption — 12.6; 18.85 MME
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
One common anesthetic that is performed for total knee replacement surgery is spinal anesthesia with an adductor canal regional block, which involves injecting numbing medication in the thigh region for pain control after surgery. The aim of this study is to determine whether the addition of another regional block called obturator nerve block, which involves injecting numbing medication in the upper thigh region, will improve pain control after surgery while not sacrificing mobility after surgery.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Morphine Equivalence Consumption |
12.6; 18.85 | — |
| SECONDARY Pain Score |
0.17; 0.23; 2.27; 2.77; 4.10; 5.13 | — |
| SECONDARY Number of Participants With Nausea or Vomiting |
11; 16 | — |
| SECONDARY Time to Ambulation |
8.98; 7.87 | — |
| SECONDARY Time to Breakthrough Pain Medication |
872.54; 510.13 | — |
| SECONDARY Analgesia Satisfaction Score |
9.24; 8.59 | — |
Eligibility Criteria
Inclusion Criteria
- Patients scheduled to undergo total knee arthroplasty
- Planned use of regional anesthesia for procedure
- Willing and able to provide informed consent
Exclusion Criteria
- Patients on immunosuppressive therapy
- Patients with history of diabetes
- Patients with lower limb neuropathy
- Patients with history of chronic opioid use for > 3 months, including but not limited to, fentanyl, morphine, oxycodone, methadone
- Patients with known allergy or intolerance to any drug used in the study
- Patients with history of alcohol or drug abuse
- Patients with history of intolerance of nonsteroidal anti-inflammatory drugs
- Patients with hepatic or renal insufficiency
- ASA score of 4 or greater
Data sourced from ClinicalTrials.gov (NCT03326999). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.