N/A
N=110
Cognitive Rehabilitation for PD
Parkinson's Disease
Bottom Line
View on ClinicalTrials.gov: NCT03335150 ↗Enrolled (actual)
110
Serious AEs
0.9%
Results posted
Jun 2020
Primary outcome: Primary: Wechsler Adult Intelligence Scale-IV (WAIS-IV) Matrix Reasoning Test Total Scaled Score — 0.22; 0.42 score on a scale — p=0.6662
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- CogSMART-PD (Behavioral); Supportive Care (Behavioral)
- Age
- Adult, Older Adult · 40+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Apr 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Wechsler Adult Intelligence Scale-IV (WAIS-IV) Matrix Reasoning Test Total Scaled Score |
0.22; 0.42 | 0.6662 |
| SECONDARY Delis-Kaplan Executive Functioning System (D-KEFS): 20 Questions Test Total Questions Asked Scaled Score |
-0.09; 1.06 | 0.0496 sig |
| SECONDARY Informant Questionnaire on Cognitive Decline in the Elderly-Self Report (IQCODE-SR) Total Score |
-5.51; -8.86 | 0.047 sig |
| SECONDARY Cognitive Problems and Strategies Assessment (CPSA) Memory Strategies Use Score |
-0.24; 10.17 | 0.001 sig |
| SECONDARY Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) Total Score |
-4.49; -10.46 | 0.020 sig |
| SECONDARY Memory for Intention Test (MIST) Total Score |
4; 2.82 | 0.444 |
| SECONDARY World Health Organization Quality of Life (WHOQOL)-BREF Psychological Domain Transformed Score |
4.02; 0.04 | 0.073 |
| SECONDARY Parkinson's Disease Questionnaire-39 (PDQ-39) Total Score |
-2.31; -2.69 | 0.82 |
| SECONDARY Neuropsychiatric Inventory-Questionnaire (NPI-Q) Total Month Score |
1.82; -2.30 | 0.0263 sig |
Summary
To investigate the effectiveness of a novel compensatory cognitive rehabilitation program for individuals with Parkinson's disease (PD) and mild cognitive impairment (MCI).
Eligibility Criteria
Inclusion Criteria
- Diagnosis of Parkinson's disease
- Mild Cognitive Impairment
- Over 40 years of age
- Fluent English speaker
Exclusion Criteria
Other neurological conditions (e.g., stroke) besides Parkinson's disease
Data sourced from ClinicalTrials.gov (NCT03335150). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.