N/A
Completed N=249
Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention
Source: ClinicalTrials.gov NCT03336268 ↗Enrolled (actual)
249
Serious AEs
65.0%
Results posted
Apr 2023
Primary outcomePrimary: Opioid Overdose — 18; 9; 10; 6 Participants
Summary
The investigators seek to assess the effectiveness of Project POINT (Planned Outreach, Intervention, Naloxone, and Treatment). As originated in Indianapolis, Project POINT is a collaboration between Indianapolis Emergency Medical Services (EMS), the Eskenazi Emergency Department, Midtown Mental Health, and researchers at Indiana University. POINT is a quality improvement initiative that connects trained outreach workers with emergency department (ED) patients who experienced a non-fatal overdose. A member of the POINT team (a recovery coach or care coordinator with specialized training) meets patients after they have experienced an opioid overdose and, following a model of patient-centered care, offers them a range of evidence-based services including a brief assessment of high-risk behaviors, Hepatitis C and HIV testing, harm reduction counseling informed by motivational interviewing, and treatment referrals with follow-up to either a medication for opioid use disorder (MOUD) provider, detoxification services, or an inpatient treatment setting
The primary goal of this project is the establishment of POINT as an effective and scalable intervention for engaging patients in MAT. This study employs a Hybrid Type 1 effectiveness implementation design to take full advantage of current POINT expansion efforts currently happening in Indiana. The goal of this study is to replicate POINT in new hospitals and test its feasibility through (a) assessment of the chosen implementation strategy and (b) the testing of research protocols and secondary data collection procedures.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Opioid Overdose |
18; 9; 10; 6; 5; 4 | — |
| SECONDARY Medication for Opioid Use Disorder (MOUD) Engagement |
46; 16; 36; 9; 24; 7 | — |
| SECONDARY Duration of Medication for Opioid Use Disorder (MOUD) Engagement |
45.0; 44.6; 41.0; 29.0; 16.0; 36.9 | — |
| SECONDARY Emergency Department Presentations |
99; 52; 77; 43; 55; 30 | — |
| SECONDARY Inpatient Hospital Admissions |
44; 23; 29; 17; 21; 9 | — |
| SECONDARY Time to Relapse |
0.85; 0.84; 0.77; 0.74 | — |
| SECONDARY Medicaid Enrollment for Participants Without Insurance |
10; 7; 13; 8; 16; 15 | — |
| SECONDARY Child Welfare Involvement |
20; 13; 19; 12; 10; 8 | — |
| SECONDARY Incarceration |
88.0; 73.5; 39.0; 30.5; 10.0; 18.0 | — |
Eligibility Criteria
Inclusion Criteria
- Revived from a drug overdose or admitted to the ED for an opioid-related health issue, including opioid withdrawal, abscess (from IV opioid use), endocarditis (from IV opioid use), or active opioid intoxication
- Score at least "1" on the DSM-5 for Opioid Use Disorder screening tool
- Eligible for discharge from the Methodist or Ball Memorial Hospital Emergency Department and deemed able to speak to research staff by ED staff
- Be 18 or older
- Be medically stable (i.e., cleared to leave the ED by a physician) and capable of providing consent.
Exclusion Criteria
(a) Unable to answer the 3 study competency questions that indicate capability of providing consent.
(Individuals discharged from the ED during a POINT shift who do not wish to participate in the study are still eligible to receive POINT services.)
Data sourced from ClinicalTrials.gov (NCT03336268). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.