N/A
Completed N=160
The Effect of Remote Ischemic Preconditioning in Living Donor Hepatectomy
Tissue Donors · Liver Transplantation · Ischemia-Reperfusion Injury
Source: ClinicalTrials.gov NCT03386435 ↗
Enrolled (actual)
160
Serious AEs
0.0%
Results posted
Aug 2019
Primary outcomePrimary: Postopera The Maximal Aspartate Aminotransferase Level Within 7 Postoperative Days — 145; 152 IU/L
Summary
Liver transplantation is the gold standard treatment for patients with end-stage liver disease. Despite its outstanding success, liver transplantation still entails certain complications including ischemia-reperfusion injury. Remote ischemic preconditioning is a novel and simple therapeutic method to lessen the harmful effects of ischemia-reperfusion injury, however, the majority of remote ischemic preconditioning studies on hepatic ischemia-reperfusion injury have been animal studies. Therefore, our aim was to assess the effects of remote ischemic preconditioning on postoperative liver function in living donor hepatectomy.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Postopera The Maximal Aspartate Aminotransferase Level Within 7 Postoperative Days |
145; 152 | — |
| PRIMARY The Maximal Alanine Aminotransferase Level Within 7 Postoperative Days |
148; 152 | — |
| SECONDARY Number of Participants With Delayed Recovery of Liver Function |
5; 0 | — |
| SECONDARY Postoperative Liver Regeneration |
83.3; 94.9 | — |
Eligibility Criteria
Inclusion Criteria
- Donors who plan to have living right hepatectomy for liver transplantation.
- age : between 18 to 60 years.
Exclusion Criteria
- donors who plan to donate left lobe
- donors who plan to have laparoscopic right hepatectomy
- donors who cannot proceed remote ischemic preconditioning
Data sourced from ClinicalTrials.gov (NCT03386435). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.