N/A N=50 Randomized Supportive Care

Stress and CKD Among African Americans

Chronic Kidney Disease

Bottom Line

View on ClinicalTrials.gov: NCT03387319 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2020

Primary outcome: Primary: Change in Subjective Units of Distress Scale (SUDS) Score — 2.92; 3.12 score on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Racialized Stressful Event Recall (Behavioral); Non-Racialized Stressful Event Recall (Behavioral)
Age: Adult, Older Adult · 25+ yrs
Sex: All
Sponsor: Emory University
Primary completion: Apr 2019

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Subjective Units of Distress Scale (SUDS) Score	2.92; 3.12	—
PRIMARY Change in Cooper's Racism Recall Scale Score	6.24; 5.48	—
PRIMARY Change in Monocyte Chemoattractant Protein-1 (MCP-1) Level	193.12; 217.31	—
PRIMARY Change in Interleukin-6 (IL-6) Level	2.23; 2.11	—
PRIMARY Change in Soluble Urokinase-type Plasminogen Activator Receptor (suPAR) Level	4.18; 4.50	—
PRIMARY Change in Systolic Blood Pressure	11.79; 15.72	—
PRIMARY Change in Diastolic Blood Pressure	5.52; 7.59	—

Summary

The goal of this study is to determine whether experiencing stress from discrimination may increase chronic kidney disease (CKD) progression in African Americans. Study participation occurs over the course of 2 days, and participant time burden is expected to be about 4.5 hours, plus a 24-hour period of wearing a blood pressure monitor.

Eligibility Criteria

Inclusion Criteria

Patient at Emory University Hospital Midtown
Self-identify as African American or Black
Estimated glomerular filtration rate (eGFR) ≥ 15, or <90

Exclusion Criteria

Mental disorder that prevents the completion of the Computer Assisted Personal Interview (CAPI) and the stressful recall manipulation
Currently on maintenance dialysis
Unable or unwilling to undergo intravenous catheterization

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03387319). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.