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N/A N=15 Randomized Single-blind Prevention

The Acute Effects of Food Structure on Post Prandial Glucose and Subsequent Metabolic Responses

Obesity

Bottom Line

View on ClinicalTrials.gov: NCT03424187 ↗
Enrolled (actual)
15
Serious AEs
0.0%
Results posted
Apr 2021
Primary outcome: Primary: Post-prandial Glucose Concentrations — 4.9; 4.8; 4.9; 5.01 mmol/l

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
chickpea (Dietary_supplement)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Imperial College London
Primary completion
May 2017

Outcome Measures

OutcomeResultp-value
PRIMARY
Post-prandial Glucose Concentrations		 4.9; 4.8; 4.9; 5.01; 5.1; 5.4 —
PRIMARY
Post-prandial Blood Insulin Concentrations		 9.3; 10.3; 8.8; 16.8; 20; 26.24 —
SECONDARY
Post-prandial Gut Hormone Gastric Inhibitory Polypeptide (GIP)		 43.02; 47; 102.6; 181.3; 343.7; 516.2 —
SECONDARY
Post-prandial Gut Hormone Glucagon-like Peptide 1 (GLP-1)		 67.3; 85.3; 80.8; 122.8; 98.7; 91.7 —
SECONDARY
Energy Intake at a Meal Given in Excess		 628.03; 681.9; 724.7 —

Summary

Aims: To investigate the effects of different food structures on glucose concentrations and subsequent metabolic responses including insulin,GIP, GLP-1 DESIGN: A randomised, controlled, clinical trial.

Eligibility Criteria

Inclusion Criteria

  • Gender: male and female
  • Age ≥ 18 years ≤ 65 years
  • Normal weight as classified by BMI 20-29.9 kg/m2
  • Healthy, not diagnosed with any chronic diseases assessed as appropriate for inclusion, based on the pre-study screening.
  • Willingness and ability to understand, participate and to comply with the study requirements
  • Willingness and ability to give written informed consent

Exclusion Criteria

  • Has thyroid defects
  • Under hormone or steroids therapy
  • Is pregnant or lactating (female)
  • Had given birth within the past year (female)
  • Is taking drugs that could affect appetite or plasma glucose levels.
  • Is taking natural remedies that modulate appetite or plasma glucose levels.
  • Has excessive alcohol intake
  • Had blood donation within 12wks prior to start date
  • Psychiatric illness
  • Smokers
  • History of any disease with unknown outcome
  • Has diabetes
  • Has nut allergy
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03424187). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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