Mode
Text Size
Log in / Sign up
N/A N=379 Randomized Single-blind Supportive Care

Comparative Effectiveness Study Telerehab Versus Conventional

Multiple Sclerosis

Enrolled (actual)
379
Serious AEs
2.6%
Results posted
Dec 2024
Primary outcome: Primary: Timed 25 Foot Walk Test (T25FWT) — 2.88; 2.62; 3.41; 3.26 feet per second — p=<0.01

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Exercise program for people with MS (Behavioral)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Shepherd Center, Atlanta GA
Primary completion
Sep 2023

Outcome Measures

OutcomeResultp-value
PRIMARY
Timed 25 Foot Walk Test (T25FWT)
2.88; 2.62; 3.41; 3.26 <0.01 sig
SECONDARY
Six Minute Walk Test (6MWT)
963.3; 884.2; 1099.6; 1027.1 0.16
SECONDARY
Multiple Sclerosis Walking Scale (MSWS)-12 Questionnaire
61.36; 62.45; 53.54; 58.25 0.13
SECONDARY
Godin Leisure-Time Physical Activity (LTPA) Questionnaire
7.48; 7.56; 23.09; 22.21 0.70
SECONDARY
Quality of Life in Neurological Disorders (Neuro-QOL) Survey
16.88; 17.19; 15.41; 14.75; 13.58; 13.90 0.43
SECONDARY
Multiple Sclerosis Impact Scale (MSIS)-29
39.63; 41.59; 32.18; 34.65; 31.71; 33.01 0.34
SECONDARY
Modified Fatigue Impact Scale (MFIS)
14.54; 14.96; 12.00; 11.63; 20.02; 20.98 0.74
SECONDARY
Expanded Disability Status Scale (EDSS)
5.32; 5.25; 5.02; 5.04 0.87
SECONDARY
Patient Determined Disease Steps (PDDS)
4.26; 4.28; 1.66; 2.19 0.05

Summary

This study aims to compare the effectiveness of an exercise program delivered in a conventional facility-based format versus a telerehabilitation format, which takes place in the home. Exercise can improve mobility and perhaps decrease the rate and extent of disability in people with MS. Evidence shows that traditional, facility-based exercise training may help people with MS consistently participate in exercise or to exercise at a higher, more intense level. Despite this evidence, lack of access to facility-based exercise programs may make it difficult for people with MS to engage in exercise.Telerehabilitation (telerehab) has great potential to overcome challenges associated with facility-based programs. Telerehab can include videoconferencing, remote monitoring of signs and activity, and dissemination of specialized and individualized information via electronic mechanisms, such as smartphones and computers. Both facility-based and telerehab exercise training have yielded positive results in people with MS, but have not been compared head-to-head. The current study will fill this gap in the evidence base and compare the outcomes of delivering the same exercise interventions in a facility or in the home/community using a telerehab approach. The interventions are designed to be identical in content, with the only difference being the mode of training delivery.

Eligibility Criteria

Inclusion Criteria

  • Mild to moderate MS
  • Has limitations in walking but can walk 25 feet
  • Does not participate in a rigorous exercise program
  • Can travel to trial site for assessments and training

Exclusion Criteria

  • Relapse in the past 30 days
  • Other neurological or musculoskeletal disorders
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03468868). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

Back to search