Aging impacts multiple sclerosis pathobiology by shifting inflammation toward chronic, compartmentalized neuroinflammation and neurodegeneration
New research explores how aging changes multiple sclerosis treatment
This narrative review examines the impact of aging on the immunological and neuroinflammatory microenvironment in older patients with multip…
As people age, multiple sclerosis can change from sudden flare-ups to a slow, steady progression of nerve damage.
Menopause does not appear to be a distinct clinical inflection point for multiple sclerosis progression
Menopause does not appear to be a turning point for MS
This narrative review examines the impact of menopause and biological aging on women with multiple sclerosis. The authors conclude that whil…
While menopause can make symptoms harder to manage, it is not a clear biological turning point for the progression of multiple sclerosis.
Nutrient and metabolite interventions for neurodegenerative diseases show inconsistent clinical translation
Dietary nutrients show mixed results for brain diseases in lab and early human data
This narrative review synthesizes evidence on nutrients and metabolites for Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic la…
Nutrients like vitamins and marine compounds show promise in labs, but human evidence for brain diseases remains inconsistent and unclear.
High-dose ocrelizumab 1200/1800 mg shows no significant difference in disability progression versus 600 mg in MS
High-dose ocrelizumab did not further reduce disability progression in multiple sclerosis patients
This phase 3b randomized controlled trial in 860 and 753 patients with relapsing or primary progressive multiple sclerosis found that high-d…
A large trial found that higher doses of ocrelizumab did not lower the risk of disability progression compared to the standard dose in multi…
Ocrelizumab reduces disability progression risk in primary progressive multiple sclerosis versus placebo
Ocrelizumab reduces disability risk for primary progressive multiple sclerosis patients
This phase 3b trial evaluated intravenous ocrelizumab versus placebo in patients with primary progressive multiple sclerosis. The study foun…
A large trial found ocrelizumab significantly lowers the risk of disability progression in patients with primary progressive multiple sclero…
T cell-microglial interactions drive aging and myelin changes in neurodegeneration models
Aging changes brain cells and invites immune cells that hurt nerve repair
This narrative review synthesizes evidence from murine models on T cell-microglial interactions in aging and neurodegeneration. It argues th…
Aging alters brain cell signals and brings in immune cells that damage myelin and stop nerve repair in mouse models.
NINJ1 targeting shows potential for multiple sclerosis and other neurological conditions but faces significant knowledge gaps
NINJ1 targeting shows promise for multiple sclerosis and other brain injuries
This narrative review examines NINJ1 targeting as a therapeutic strategy for multiple sclerosis, ischemic stroke, traumatic brain injury, sp…
A review suggests NINJ1 targeting could help treat multiple sclerosis, stroke, and other brain injuries, though more research is needed.
Narrative review discusses MS continuum concepts for high-risk individuals
New review suggests viewing MS as a continuum helps monitor those at higher risk
This narrative review addresses multiple sclerosis in individuals at higher risk for the condition. The authors argue that conceptualizing M…
A new review suggests that seeing multiple sclerosis as a continuous process could help doctors better monitor people at higher risk for the…
Ibudilast metabolomics in progressive multiple sclerosis brain atrophy trial
Metabolite levels linked to slower brain shrinkage in MS patients
This randomized trial in 244 participants with progressive multiple sclerosis evaluated oral ibudilast versus placebo over 96 weeks. Higher …
Higher baseline levels of certain metabolites were associated with slower brain shrinkage in people with progressive multiple sclerosis taki…
Network meta-analysis finds acupoint stimulation may improve function and fatigue in multiple sclerosis
Acupuncture Shows Promise for Multiple Sclerosis Symptoms
This network meta-analysis of 1384 patients with multiple sclerosis suggests that acupoint stimulation therapies combined with standard phar…
A review of 18 trials finds acupoint therapies may improve mobility and fatigue in MS, but evidence is limited.
Marburg MS case shows treatment challenges and fatal outcome
A Rare MS Variant Defied Treatment Until This Switch
A 46-year-old woman with aggressive Marburg MS faced treatment-limiting toxicity and died despite multiple therapies, highlighting urgent ca…
A woman with a rare, aggressive form of multiple sclerosis tried many treatments without success, and doctors tried a new approach too late.
Review of SC-EVs for SLE and MS highlights immunomodulatory mechanisms and neuroprotective potential
New cell-free therapy could calm immune fires in lupus and MS
This narrative review examines stem cell-derived extracellular vesicles (SC-EVs) for systemic lupus erythematosus and multiple sclerosis. Th…
Tiny cargo from stem cells might stop the immune system from attacking the brain and joints in lupus and MS patients
Questions about Multiple Sclerosis
How does oral cladribine change immune cells in relapsing multiple sclerosis?
Oral cladribine depletes certain B and T cells in the blood and CSF, reduces microglial activation, and allows recovery of naive B cells, which may help control relapsing MS.
Full answer →What active therapeutic interventions are available for Multiple Sclerosis patients in inpatient rehabilitation?
Inpatient rehabilitation for MS includes gait training, robot-assisted therapy, strength, balance, and aerobic exercises, all showing mobility and fatigue benefits.
Full answer →Are CAR-T cell therapies currently being used to treat Multiple Sclerosis according to recent reviews?
CAR-T cell therapies are not yet approved for MS but are being tested in clinical trials, with early results showing safety and potential benefit.
Full answer →Can aerobic or strength training help reduce fatigue in people with Multiple Sclerosis?
Yes, both aerobic and strength training can reduce fatigue in people with multiple sclerosis, with studies showing similar benefits from each modality.
Full answer →How much has the incidence of Multiple Sclerosis in women of childbearing age increased since 1990?
The incidence of Multiple Sclerosis in women of childbearing age has increased by 48% from 1990 to 2021, according to a global burden of disease study.
Full answer →What is the success rate for pain relief in Multiple Sclerosis patients treated with microvascular decompression?
Microvascular decompression for trigeminal neuralgia in multiple sclerosis patients has a long-term pain-free success rate of about 30.2%, based on a 2024 systematic review.
Full answer →All Multiple Sclerosis Articles
- Aging impacts multiple sclerosis pathobiology by shifting inflammation toward chronic, compartmentalized neuroinflammation and neurodegeneration
- Menopause does not appear to be a distinct clinical inflection point for multiple sclerosis progression
- Nutrient and metabolite interventions for neurodegenerative diseases show inconsistent clinical translation
- NINJ1 targeting shows potential for multiple sclerosis and other neurological conditions but faces significant knowledge gaps
- T cell-microglial interactions drive aging and myelin changes in neurodegeneration models
- High-dose ocrelizumab 1200/1800 mg shows no significant difference in disability progression versus 600 mg in MS
- Ocrelizumab reduces disability progression risk in primary progressive multiple sclerosis versus placebo
- Narrative review discusses MS continuum concepts for high-risk individuals
- Ibudilast metabolomics in progressive multiple sclerosis brain atrophy trial
- Network meta-analysis finds acupoint stimulation may improve function and fatigue in multiple sclerosis
- Marburg MS case shows treatment challenges and fatal outcome
- Review of SC-EVs for SLE and MS highlights immunomodulatory mechanisms and neuroprotective potential
- Narrative review discusses jump assessment for multiple sclerosis disability evaluation
- Ocrelizumab treatment in multiple sclerosis shows disability improvement in relapsing forms
- Narrative review discusses CAR-T and HSC therapies for cancer and autoimmune conditions
- Systematic review and meta-analysis finds 30.2% success rate for MVD in TN-MS patients
- Global MS burden in women of childbearing age rises 48% from 1990 to 2021
- Narrative review explores ferroptosis-immune crosstalk in CNS diseases as therapeutic target
- Review of active therapeutic interventions in 255 people with multiple sclerosis undergoing inpatient rehabilitation
- Frexalimab study validates PROMIS-Fatigue-MS-8a and MSIS-29v2 in relapsing multiple sclerosis patients
- Aerobic and strength training reduce fatigue in multiple sclerosis patients
- Laughter yoga reduced fatigue in people with multiple sclerosis in a randomized controlled trial
- Exercise training improves cognition and fatigue in older adults with multiple sclerosis
- Meta-analysis finds PLISSIT counseling improves sexual life in women with MS
- Sleep efficiency improved with mindfulness in multiple sclerosis patients according to a meta-analysis
- Meta-analysis shows reduced stress-induced autonomic responses in people with multiple sclerosis compared to controls
- Narrative review discusses multi-target strategies for multiple sclerosis progression
- Mini-review explores oxidized mannan-conjugated MOG peptide for multiple sclerosis immunotherapy
- Plasma cytokines and CSF ROS measured in MS phenotypes show associations with disability and cognition
- Composite Endpoints Show Weaker Treatment Effects Than EDSS Alone in Multiple Sclerosis Trials
- Narrative review notes lack of comprehensive synthesis on antioxidant strategies for multiple sclerosis
- Simulation study of frontier AI models analyzing 10,000 synthetic Multiple Sclerosis cases reveals variable diagnostic safety
- Observational study finds lower delayed recall ratios in multiple sclerosis patients versus controls
- Systematic review and meta-analysis of CBT for depression in multiple sclerosis patients
- Narrative review examines resveratrol in Alzheimer's, Parkinson's, MS, and cerebral ischemia with noted limitations
- Observational study abstract reports AI RNA sequencing diagnostic accuracy in multiple sclerosis and neuromyelitis optica
- Higher serum MOG protein levels associated with MS diagnosis and disease activity compared to controls
- Elevated CSF and blood sCD27 associated with autoimmune disease in severe psychiatric disorders and MS
- Narrative review explores multimodal approaches for autoimmune diseases including rheumatoid arthritis and Crohn's
- Oral cladribine reshapes CSF immune cell composition in relapsing multiple sclerosis
- Protocol for pilot RCT of neuromodulation-augmented balance training in ambulatory people with multiple sclerosis
- EBV DNA positivity links to MS risk genes in a cross-ancestry study of 617,186 participants
- Real-world cohort examines Alemtuzumab effects on bowel/bladder function and latent progressive trajectories in MS patients
- MRI outcomes show weak association with disability in primary progressive multiple sclerosis patients
- Systematic Review Examines T-Cell Mechanisms and Therapies in Multiple Sclerosis
- 6-week multimodal exercise training feasible for frail people with multiple sclerosis in pilot RCT
- Meta-analysis finds respiratory muscle training improves some lung function measures in multiple sclerosis
- REDDI pipeline improves balanced accuracy for classifying MCI, MS, Parkinson's, and ALS using MEG data
- Home-based e-based exercise protocol feasibility study for patients with multiple sclerosis and comorbidities
- Rituximab exposure is associated with serum sickness in patients with multiple sclerosis, nephrotic syndrome, or immune thrombocytopenia
- Chiropractic thoracic spinal manipulation showed moderate effects on cytokines in a pilot RRMS trial
- Network meta-analysis of six exercise modalities in females with multiple sclerosis shows improvements in fatigue, quality of life, balance, depression, and mental health
- Dimethyl fumarate with slow titration improves treatment satisfaction and quality of life in Iranian MS patients
- Cladribine tablets maintain stable patient-reported outcomes in highly active MS over 52 weeks
- Sex differences in disability and demographics observed in a Swiss Multiple Sclerosis Cohort
- Respiratory muscle training improves respiratory muscle strength and pulmonary function in multiple sclerosis patients
- China's rehabilitation needs for neurological disorders increased significantly from 1990 to 2021
- Luteolin shows neuroprotective potential in preclinical models for Alzheimer's, Parkinson's, Huntington's, and multiple sclerosis
- Normative MRI modelling identifies critical brain volume deviations associated with disability in multiple sclerosis
- FDG-PET reveals dysregulated glucose metabolism as a common feature across late-onset neurodegenerative diseases with unique patterns
- Plastic changes in brainstem reticular formation may be involved in spasticity onset across stroke and spinal cord injury
- CSF proteomic signatures show potential for MS diagnosis and prognosis in cohort study
- High-dose melatonin linked to hepatotoxicity in small PP-MS trial, prompting early halt
- FDA Approves Kesimpta (ofatumumab) for Relapsing Forms of Multiple Sclerosis in Adults
- Online behavioral intervention increases physical activity and improves depression in newly diagnosed multiple sclerosis
- Neuromuscular electrostimulation plus swallowing therapy may benefit dysphagia in severely disabled MS patients
- Percutaneous balloon compression shows initial pain relief in multiple sclerosis-related trigeminal neuralgia
- Ponesimod Shows Sustained Efficacy and Safety in RMS Over 5 Years