Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea

Inclusion Criteria

Participants must meet all of the following criteria to be included in this study:

• Male or female, age ≥18 years and ≤90 years at the time of informed consent
• Voluntary agreement and ability to provide written informed consent
• Reports habitually sleeping for at least 5.5 hours per night
• Agrees to stay in bed for 7 hours per night for the duration of treatment
• Reports habitual bedtime between 21: 00 and 01:00
• Peripheral capillary oxygen saturation (SpO2) ≥94% assessed as part of vital signs at Screening Visit 1

Additional Inclusion Criteria (Healthy Volunteer [HV] Cohort):

• Body mass index (BMI) less than or equal to 32 kilograms per meters squared (kg/m^2)
• On screening polysomnography (PSG) (Screening Visit 2): apnea-hypopnea index (AHI) 15
• History of or suspected drug or alcohol use disorder within approximately 2 previous years
• A positive urine drug test or breath alcohol test at Screening or Baseline, or unwilling to refrain from use of recreational drugs during the study
• Known to be human immunodeficiency virus positive
• Active viral hepatitis (B or C) as demonstrated by positive viral serology at Screening
• A prolonged QT/corrected QT (QTc) interval (QT interval corrected for heart rate using Fridericia's formula [QTcF] >450 milliseconds [ms]) as demonstrated by a repeated electrocardiogram (ECG) at Screening (repeated if initial ECG indicates a QTcF interval >450 ms)
• Comorbid nocturia resulting in the need to get out of bed to use the bathroom more than 3 times during the night
• Any history of medical or psychiatric condition that in the opinion of the investigator could affect the participant's safety or interfere with the study assessments
• Any suicidal ideation with intent to act with or without a plan, current or within 6 months before the Columbia - Suicide Severity Rating Scale (C-SSRS) administration during the Screening (e.g., answering "Yes" to questions 4 or 5 on the Suicidal Ideation section of the C-SSRS
• Any suicidal behavior (per the Suicidal Behavior section of the C-SSRS) within 10 years of Screening
• Scheduled for surgery during the study that requires general anesthesia or administration of prohibited medications
• Used any prohibited prescription or over-the-counter medications within 1 week or 5 half-lives, whichever is longer, before the Screening PSG
• Hypersensitivity to lemborexant or excipients
• Currently enrolled in another interventional clinical trial or used any investigational drug or device within 30 days or 5 times the half-life, whichever is longer preceding informed consent
• Previously participated in other clinical trial of lemborexant
• Is unable to avoid working a night shift within 2 weeks before the Screening PSG, or between the Screening PSG and End-of-Study
• Has travelled across 3 or more time zones in the week prior to Screening, or plans to travel across more than 3 time zones during the study
• Clinically significant findings based on vital signs, physical examination, ECG, or clinical laboratory tests

Additional Exclusion Criteria (HV Cohort):

• Any valid event of SpO2 <90% during the Screening PSG
• Current evidence of a clinically significant, active respiratory disorder. This includes bronchiectasis, emphysema, asthma, chronic obstructive pulmonary disease, or any other pulmonary disorder identified by review of medical history, physical examination, and which in the opinion of the investigator, could compromise the participant's safety or interfere with study assessments
• Presence of significant illness (including insomnia) that requires treatment or may influence the study assessments (e.g., psychiatric disorders, disorders of the gastrointestinal tract, liver, kidney, respiratory system, endocrine system, hematological system, neurological system, cardiovascular system, or a congenital abnormality), malignancy within the past 5 years (other than adequately treated basal cell carcinoma or in situ carcinoma of the c