Phase 4
Completed N=1,561
MAST Trial: Multi-modal Analgesic Strategies in Trauma
Nonspecific Pain Post Traumatic Injury
Source: ClinicalTrials.gov NCT03472469 ↗
Enrolled (actual)
1,561
Serious AEs
4.2%
Results posted
Jun 2021
Primary outcomePrimary: Opioid Use Per Day — 48; 34 MME per day
◆ Published Evidence
Established
54citations · ~11 / year
Multi-Modal Analgesic Strategy for Trauma: A Pragmatic Randomized Clinical Trial.
Summary
This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared [original multimodal pain regimen (MMPR) compared to multi-modal analgesic strategies for trauma (MAST) MMPR].
Linked Publications
-
Multi-Modal Analgesic Strategy for Trauma: A Pragmatic Randomized Clinical Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Opioid Use Per Day |
48; 34 | — |
| SECONDARY Pain as Assessed by Score on the Numeric Rating Scale (NRS) |
3.3; 3.3 | — |
| SECONDARY Pain as Assessed by Score on the Behavioral Pain Scale (BPS) |
2.5; 2.3 | — |
| SECONDARY Number of Participants Discharged From the Hospital With an Opioid Prescription |
527; 476 | — |
| SECONDARY Number of Participants With Any Opioid-related Complications |
16; 16; 30; 31; 18; 13 | — |
| SECONDARY Overall Costs |
20093; 19561 | — |
| SECONDARY Pharmacy Costs |
507; 397 | — |
| SECONDARY Number of Ventilator Days |
0.08; 0.06 | — |
| SECONDARY Number of Hospital Days |
4.97; 5.12 | — |
| SECONDARY Number of Intensive Care Unti (ICU) Days |
0.21; 0.21 | — |
| SECONDARY Degree to Which Function is Limited by Pain as Assessed by Percent of Predicted Daily Incentive Spirometry Volumes (Which is Based on Ideal Body Weight) |
— | — |
| SECONDARY Degree to Which Function is Limited by Pain as Indicated by Number of Participants Who Failed to Work With Physical Therapist Due to Pain |
— | — |
Eligibility Criteria
Inclusion Criteria
- All patients admitted to the trauma service who are 16 years and older.
Exclusion Criteria
- pregnant
- prisoner
- patients placed in observation (i.e. not admitted to the hospital)
Data sourced from ClinicalTrials.gov (NCT03472469) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.