Phase 4 N=1,561 Randomized Treatment

MAST Trial: Multi-modal Analgesic Strategies in Trauma

Nonspecific Pain Post Traumatic Injury

Bottom Line

View on ClinicalTrials.gov: NCT03472469 ↗

Enrolled (actual)

1,561

Serious AEs

4.2%

Results posted

Jun 2021

Primary outcome: Primary: Opioid Use Per Day — 48; 34 MME per day

Study Design & Population

Study type: Interventional
Phase: Phase 4
Interventions: Acetaminophen IV/PO (Drug); Acetaminophen PO (Drug); Ketorolac (Drug); Celebrex (Drug); Naproxen (Drug); Tramadol (Drug); Pregabalin (Drug); Gabapentin (Drug); Lidocaine (Drug); Opioids (Drug); Regional anesthesia (Drug)
Age: Pediatric, Adult, Older Adult · 16+ yrs
Sex: All
Sponsor: The University of Texas Health Science Center, Houston
Primary completion: Jul 2019

Outcome Measures

Outcome	Result	p-value
PRIMARY Opioid Use Per Day	48; 34	—
SECONDARY Pain as Assessed by Score on the Numeric Rating Scale (NRS)	3.3; 3.3	—
SECONDARY Pain as Assessed by Score on the Behavioral Pain Scale (BPS)	2.5; 2.3	—
SECONDARY Number of Participants Discharged From the Hospital With an Opioid Prescription	527; 476	—
SECONDARY Number of Participants With Any Opioid-related Complications	16; 16; 30; 31; 18; 13	—
SECONDARY Overall Costs	20093; 19561	—
SECONDARY Pharmacy Costs	507; 397	—
SECONDARY Number of Ventilator Days	0.08; 0.06	—
SECONDARY Number of Hospital Days	4.97; 5.12	—
SECONDARY Number of Intensive Care Unti (ICU) Days	0.21; 0.21	—
SECONDARY Degree to Which Function is Limited by Pain as Assessed by Percent of Predicted Daily Incentive Spirometry Volumes (Which is Based on Ideal Body Weight)	—	—
SECONDARY Degree to Which Function is Limited by Pain as Indicated by Number of Participants Who Failed to Work With Physical Therapist Due to Pain	—	—

Summary

This is a comparative effectiveness study of current pain management strategies in acutely injured trauma patients. Two different multi-modal, opioid minimizing analgesic strategies will be compared [original multimodal pain regimen (MMPR) compared to multi-modal analgesic strategies for trauma (MAST) MMPR].

Eligibility Criteria

Inclusion Criteria

All patients admitted to the trauma service who are 16 years and older.

Exclusion Criteria

pregnant
prisoner
patients placed in observation (i.e. not admitted to the hospital)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03472469). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.