N/A N=254 Neuromodulatory Treatments for Pain Management in TBI
Chronic Pain · Traumatic Brain Injury · Posttraumatic Stress Disorder
Primary: Change in Self-reported Pain Intensity — -1.02; -0.78; -1.03 score on a scale — p=0.2852
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=542 Placebo-controlled Safety and Efficacy Study of Pregabalin in Subjects With Post-traumatic Peripheral Neuropathic Pain
Neuropathic Pain
Primary: Baseline Mean Pain Score — 6.41; 6.54 units on a scale
Phase 3 N=80 An Open-Label Study Of Celecoxib In Patients With Posttraumatic Pain
Pain
Primary: Patient Impressions at Final Visit (the Number of Participants Who Have Rated "Excellent" and "Good") — 70 Participants
N/A N=23 Intensive Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)
Stress Disorders, Post-Traumatic
Primary: McGill Pain Questionnaire — 31.91; 30.83 units on a scale
N/A N=42 Integrated Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)
Pain · Posttraumatic Stress Disorder
Primary: Clinician Administered Assessment of PTSD — 80.67; 70.83; 77.60; 74.73 units on a scale
Phase 4 N=368 P4 (Pregabalin for Peripheral Posttraumatic Pain)
Neuralgia
Primary: Weekly Mean Pain Score at End of Treatment (Week 8) From Daily Pain Diary — 4.61; 5.23 score on a scale — p=0.010
Phase 2 N=40 Sumatriptan as Treatment for Post-traumatic Headache
Post-traumatic Headache
Primary: Change in Headache Relief — 23 percentage of headaches resolved — p=.079
N/A N=7 Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia
Postoperative Pain
Primary: Change From Baseline of Surgical Site Pain Level (NRS) at Rest [Percentage of Baseline Pain] — 64; 100; 55; 69 percentage of baseline
N/A N=121 Trauma Survivors Outcomes and Support Study IV
Posttraumatic Stress Disorder · Depression · Suicide
Primary: Change in Post Traumatic Stress Disorder (PTSD) Symptoms Over the Course of the Six Months After Injury — 47.0; 47.0; 43.9; 43.6 units on a scale — p=0.05
Phase 1 N=9 TMS and Exercise for Post-stroke Pain
Chronic Post-stroke Headache
Primary: Change in Modified Rankin Scale From Baseline to Follow-up 30 Days After Last Intervention — 0; 1 units on a scale — p=0.896
N/A N=575 Persistent Pain After CS Delivery
Persistent Pain After Delivery
Primary: Persistent Pain-PERCEIVED STRESS Scores Stratified by the Rate of Recovery — 11.4; 12.9; 15.4 units on a scale — p=<0.01
Phase 3 N=140 Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery
Breast Cancer Patient
Primary: Change in Neuropathic Pain Score at 2 Months (Numeric Rating Scale 0-10) — 4.1; 4.6 units on a scale
Phase 4 N=16 Pathophysiology of Post Amputation Pain
Amputation Stumps · Neuroma
Primary: Change in Pain — -0.3; -2; -1; 1.3 units on a scale
Phase 4 N=89 Prazosin for Post-Concussive Headaches
Post-Traumatic Headache
Primary: Change From Baseline in Headache Frequency — 16.4; 18.5; -9.2; -7.4 headaches per month
N/A N=359 Pain, Psychiatric Disorders, and Disability Among Veterans With and Without Polytrauma
Chronic Pain
Primary: Numeric Rating Scales of Pain Over Past Week (11 Point Likert Scale) — 4.66; 3.80; 4.92; 3.30 units on a scale
N/A N=19 Neuromodulation and Yoga for Mild Traumatic Brain Injury and Chronic Pain
Mild Traumatic Brain Injury · Chronic Pain
Primary: Session Completion Rate — 60 number of sessions
N/A N=193 Cognitive-Behavior Therapy for Posttraumatic Headache
Post-traumatic Headache · PTSD
Primary: Headache-related Disability Scores on the Headache Impact Test 6 (HIT-6) — 66.1; 66.1; 65.2; 61.9 score on a scale — p=<0.001
Phase 2 N=21 Metoclopramide for Post-Traumatic Headache. A Pilot Study
Post-Traumatic Headache
Primary: Number of Participants With Sustained Headache Relief — 12 Participants
N/A N=57 Improving Functions in Veterans With Post-traumatic Peripheral Neuropathic Pain
Neuropathic Pain
Primary: Evaluation of Spontaneous Pain Scores — 53.52; 49.13; 41.41; 46.17 score on a scale — p=0.246
N/A N=8 Peripheral Sensory Input in Central Post Stroke Pain (CPSP)
Central Post Stroke Pain
Primary: Reduction in Spontaneous Pain Intensity After a Peripheral Nerve Block. — 6.5; 0.0 units on a scale
N/A N=116 Peripheral Nerve Stimulation(PNS) for Subacromial Impingement Syndrome(SIS)
Shoulder Pain · Shoulder Impingement Syndrome · Shoulder Tendinitis
Primary: Change in - Short Form (SF) Question 3 (BPI-SF3) — 6.90; 7.05; 3.58; 3.96 units on a scale
Phase 2 N=19 Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain
Fibromyalgia · Chronic Pain · Depression
Primary: Gracely Box Intensity Rating Scale — 13.18; 14.43; 10.64; 13.00 units on a scale
N/A N=176 One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change
Traumatic Brain Injury · Chronic Pain · Post Traumatic Stress Disorder
Primary: The Depression Anxiety and Stress Scale (DASS-21) -TOTAL Score — 28.97; 30.77 units on a scale
N/A N=19 MRI Diffusion Tensor Tractography to Monitor Peripheral Nerve Recovery After Severe Crush or Cut/Repair Nerve Injury
Nerve Injury
Primary: Michigan Hand Questionnaire (MHQ) in TPNI Subjects Post Surgery — 33; 83; 5; 75 score on a scale
N/A N=311 Risk Factors and Mechanisms for Persistent Postsurgical Pain After Total Knee Replacement
Persistent Postsurgical Pain
Primary: Number of Subjects With Post-Operative Persistent Pain (PPP) — 211; 34 Participants
N/A N=55 Pain and Function After Orthopedic Surgery
Chronic Pain
Primary: Self-reported Pain Intensity — 3 units on a scale
N/A N=92 Past Pain Experience and Perception of Experimental Pain
Schizophrenia · Major Depression
Primary: Visual Analog Scale Evaluation for the Pre-fixed Pressure Test — 2.8; 2.1; 1.2 units on a scale — p=0.121
N/A N=16 Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain
Phantom Limb Pain · Postoperative Pain · Neuroma
Primary: Average Phantom Limb Pain (PLP) Score — 4.1; 3.1; 2.2; 3.0 score on a scale
N/A N=105 NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
Musculoskeletal Pain · Pain, Chronic
Primary: Short Physical Performance Battery (SPPB) — 10.95; 10.82; 11.75 score on a scale — p=0.0561
N/A N=26 Surgical Treatment of Post-surgical Mastectomy Pain Utilizing the Regenerative Peripheral Nerve Interface
Post-Mastectomy Chronic Pain Syndrome
Primary: Change in Pain Level — 6.9; 0.6; 4.4; 2.5 score on a scale