Phase 4
Completed N=62
Comparison of Intra-articular Dexmedetomidine and Magnesium in Postoperative Pain
Postoperative Pain · Intra-articular Injection · Dexmedetomidine · Magnesium Sulfate
Source: ClinicalTrials.gov NCT03479216 ↗
Enrolled (actual)
62
Serious AEs
0.0%
Results posted
Nov 2018
Primary outcomePrimary: Postoperative Pain — 0; 0.04; 0.19; 0.23 score on a scale
◆ Published Evidence
Highly cited
374citations · ~20 / year
Dexmedetomidine: an updated review.
Summary
Arthroscopic meniscus surgeries are the most frequent orthopedic procedures. The objective of the study is to compare the effects of intraarticular local anesthetic and adjuvant (dexmedetomidine vs magnesium) combinations in postoperative pain and analgesic requirement. The investigators' hypothesis is adjuvants added to the local anesthetics decreases the total local anesthetic dose, provides more effective pain relief according to local anesthetic only, and decreases the postoperative systemic non-steroidal analgesic and opioid doses.
Linked Publications (5)
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Dexmedetomidine: an updated review.
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Effect of dexmedetomidine on postoperative pain in knee arthroscopic surgery; a randomized controlled clinical trial.
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Efficacy of dexmedetomidine for pain management in knee arthroscopy: A systematic review and meta-analysis.
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Intra-articular clonidine for post-operative analgesia following arthroscopic knee surgery: a systematic review and meta-analysis.
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Single-dose intra-articular bupivacaine plus morphine versus bupivacaine alone after arthroscopic knee surgery: a meta-analysis of randomized controlled trials.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Postoperative Pain |
0; 0.04; 0.19; 0.23; 0.81; 0.12 | — |
| SECONDARY Postoperative Opioid/NSAID Consumption |
17; 14; 0; 1 | — |
| SECONDARY Rescue Analgesic Time |
477.33; 498.46 | — |
| SECONDARY Surgery Time |
24.23; 25.58 | — |
| SECONDARY Time to the End of Spinal Anesthesia |
148.1; 147.5 | — |
| SECONDARY Mobilization |
143.27; 139.42 | — |
| SECONDARY Number of Participants With Complications Due to Intraarticular Injection |
0; 0 | — |
Eligibility Criteria
Inclusion Criteria
- age >18, 65
- patients who received general anesthesia
- diabetes
- refusal of the patient
- known allergy to the specified drugs
Data sourced from ClinicalTrials.gov (NCT03479216) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.