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N/A N=185 Randomized Single-blind Treatment

A Novel Transition Program to Reduce Disability After Stroke

Ischemic Stroke · Hemorrhagic Stroke

Bottom Line

View on ClinicalTrials.gov: NCT03485820 ↗
Enrolled (actual)
185
Serious AEs
0.0%
Results posted
Mar 2025
Primary outcome: Primary: Reintegration to Normal Living Index (RNLI) — 60.8; 61.2; 74.8; 73.9 score on a scale — p=0.76

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
COMPASS (Behavioral); Stroke education (Behavioral)
Age
Adult, Older Adult · 50+ yrs
Sex
All
Sponsor
Washington University School of Medicine
Primary completion
Dec 2023

Outcome Measures

OutcomeResultp-value
PRIMARY
Reintegration to Normal Living Index (RNLI)		 60.8; 61.2; 74.8; 73.9 0.76
SECONDARY
Stroke Impact Scale (SIS) - Activities of Daily Living (ADL) Domain		 55.3; 57.0; 66.4; 69.9 0.60
SECONDARY
In-Home Occupational Performance Evaluation (I-HOPE) - Activity Score		 0.73; 0.73; 0.77; 0.78 0.83
SECONDARY
In-Home Occupational Performance Evaluation (I-HOPE) - Performance Score		 2.42; 2.65; 3.60; 3.44 0.046 sig
SECONDARY
In-Home Occupational Performance Evaluation (I-HOPE) - Satisfaction Score		 2.24; 2.53; 3.56; 3.33 0.02 sig
SECONDARY
In-Home Occupational Performance Evaluation (I-HOPE) - Barrier Severity Score		 67.0; 64.4; 30.5; 38.4 0.07

Summary

This study evaluates a program designed to help individuals transition home from inpatient rehabilitation following an ischemic or hemorrhagic stroke. Half of the participants will receive a stroke education program while the other half will receive an environmental modifications program.

Eligibility Criteria

Inclusion Criteria

  • aged ≥50 years
  • acute ischemic or hemorrhagic stroke diagnosis
  • independent ADLs prior to stroke (premorbid Modified Rankin Scale Score ≤2)
  • plan to discharge to home

Exclusion Criteria

  • severe terminal systemic disease that limits life expectancy to < 6 months
  • previous disorder (e.g. dementia) that makes interpretation of the self-rated scales difficult or Short Blessed Test (SBT) score of 10 or less (indicating significant cognitive impairment)
  • moderate to severe Aphasia as determined by the NIHSS Best Language rating of 2 or more
  • reside in congregate living facility.
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03485820). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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