N/A N=67 Randomized Treatment

Obesity Risk in African American Women is Determined by a Diet-by-phenotype Interaction

Diet Modification

Bottom Line

View on ClinicalTrials.gov: NCT03499509 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2025

Primary outcome: Primary: Total Energy Expenditure — 2411; 2316; 2318; 2179 kcal/day

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Low Glycemic Diet (Other); High Glycemic Diet (Other)
Age: Adult, Older Adult · 19+ yrs
Sex: Female
Sponsor: University of Alabama at Birmingham
Primary completion: Apr 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Total Energy Expenditure	2411; 2316; 2318; 2179	—

Summary

The Scientific Premise of this study is that the high level of obesity displayed by African American (AA) women is due to the ability to secrete large amounts of insulin when sugary foods are consumed. When AA women eat a diet rich in starchy or sugary food (a "high-glycemic" diet that stimulates insulin secretion), the food that is eaten is stored as fat rather than being burned as fuel. The investigators previous research has suggested that AA women have an easier time losing weight and keeping it off when eating a low-glycemic diet. The proposed study will be the first randomized clinical trial to test the effect of high and low glycemic diets for weight loss and weight-loss-maintenance in obese AA women.

Eligibility Criteria

Inclusion Criteria

BMI 30-45 kg/m2
Sedentary to moderately active ( 1 pack/wk)
change in weight greater than 5 pounds in previous 3 months
presence of any condition (e.g. PCOS) or use of any medication (e.g. glucocorticoid) deemed by the project physician to interfere with study outcomes
applicants will be screened with a standard oral glucose tolerance test. If a participant's 2 hour glucose if >200, they will not be able to enroll in the study.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03499509). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.