N/A N=33 Supportive Care

Preventing Loss of Independence Through Exercise (PLIÉ) in Persons With Mild Cognitive Impairment (MCI)

Mild Cognitive Impairment

Bottom Line

View on ClinicalTrials.gov: NCT03526146 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Apr 2025

Primary outcome: Primary: Change in Alzheimer's Disease Assessment Scale-cognitive Subscale (ADAS-cog) — 2.83 score on a scale — p=0.002

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Behavioral: Preventing Loss of Independence through Exercise (PLIE) (Behavioral)
Age: Adult, Older Adult · 50+ yrs
Sex: All
Sponsor: University of California, San Francisco
Primary completion: Oct 2020

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Alzheimer's Disease Assessment Scale-cognitive Subscale (ADAS-cog)	2.83	0.002 sig
SECONDARY Short Physical Performance Battery (SPPB)	-0.8	0.047 sig
SECONDARY Interoceptive Self-Regulation, Assessed With the Multidimensional Assessment of Interoceptive Awareness, Version 2 (MAIA-2)	-0.8	0.006 sig
SECONDARY Attention Regulation, Assessed With the Multidimensional Assessment of Interoceptive Awareness, Version 2 (MAIA-2)	-0.5	0.05
SECONDARY PROMIS Social Isolation	1.7	0.009 sig

Summary

Nearly 1 in 10 older Americans have dementia, which is a devastating condition that leads to a progressive loss of independence and functional status. Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and the more-serious decline of dementia. The investigators have developed a novel, integrative exercise program called Preventing Loss of Independence through Exercise (PLIE) that incorporates elements from Eastern and Western exercise modalities and is designed to build and maintain the capacity to perform basic functional movements while increasing mindful body awareness and enhancing social connection. Pilot study results suggest that PLIE is associated with meaningful improvements in physical function, cognitive function and quality of life in individuals with dementia, as well as reduced caregiver burden. The goal of the current study is to perform a randomized, controlled trial to test the efficacy of PLIE in older adults who have MCI but who do not yet have dementia. The investigators will also investigate the neural mechanisms underlying PLIE by acquiring brain imaging measures.

Eligibility Criteria

Inclusion Criteria

diagnosis of Mild Cognitive Impairment (MCI) by primary care physician and/or neurologist
English language fluency
willing to attend PLIÉ classes 2 days/week
ambulatory and able to take 2 steps without cane or walker; living in the community in a private home or apartment

Exclusion Criteria

Behavioral or physical issues that would be disruptive or dangerous to themselves or others (e.g., active psychosis, drug abuse, severe behavioral issues)
Unable to attend 2 PLIÉ classes/week during the study period
Physical or mental health condition that would make participation difficult (e.g., active psychosis, limited life expectancy)
Contraindications to magnetic resonance imaging (MRI), including claustrophobia severe enough to prevent MRI examination, and presence of ferrometallic objects in the body that would interfere with MRI examination and/or cause a safety risk (e.g., pace makers, implanted stimulators, pumps).
Started dementia medication (cholinesterase inhibitor or memantine) in past 3 months
Planning to start/change any psychotropic medication during the study period
Current participation in another research study

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03526146). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.