Phase 4
Completed N=4
Neuroimaging the Expectancy Versus Pharmacotherapy Effect of Adderall on Cognitive Performance
Expectancy Versus Pharmacotherapy Effect of Adderall
Source: ClinicalTrials.gov NCT03530631 ↗
Enrolled (actual)
4
Serious AEs
0.0%
Results posted
Oct 2019
Primary outcomePrimary: Number of Participants Consistently Attending and Completing Four Neuroimaging Sessions — 4; 4; 4; 4 Participants
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The purpose of this balanced-placebo design study is to pilot a larger study to further explore the current evidence that stimulant medications are not cognitive enhancers, despite this rampant belief in young adults. While the lack of cognitive enhancement from stimulant medication has been documented in prior research, this study is the first to utilize neuroimaging technology to examine brain regions activated during neurocognitive tasks when participants believe they have been administered stimulant medication or placebo.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants Consistently Attending and Completing Four Neuroimaging Sessions |
4; 4; 4; 4 | — |
Eligibility Criteria
Inclusion Criteria
- Age (18-24)
- College student with at least average IQ
- Willingness to standardize caffeine intake to 100 mg on day of study
Exclusion Criteria
- Attention Deficit/Hyperactivity Disorder (ADHD)
- First degree relative with ADHD
- Unwillingness to comply with caffeine specifications
- Regular use of Adderall
- Pregnant/breastfeeding
- History of substance use disorders
- Illicit stimulant use within the last year
- Contraindications to stimulants (i.e., tics, Tourette's, cardiac disease, hypertension)
- Uncontrolled medical illness
- Active contagious infection
Data sourced from ClinicalTrials.gov (NCT03530631). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.