Clinical Trial Search

Primary: Number of Participants Consistently Attending and Completing Four Neuroimaging Sessions — 4; 4; 4; 4 Participants

Primary: Medication Event Monitoring System (MEMS®) Dosage Adherence — 42.7; 66.2 percentage of participants adherent

Primary: Conners Adult ADHD Rating Scale - Short Version (CAARS) — 50.59; 46.86; 47.32; 45.36 T score — p=<0.001

Primary: Last Three Weeks of Cocaine Abstinence Based on Urine Toxicology Results and Self Reported Use — 7; 18; 30 percentage of participants

Primary: Dyadic Parent-Child Interaction Coding System (DPICS) - Behavior Counts — 67.2; 42.1; 53.8; 40.1 behaviors

Primary: Sleep Start Time, and End Time as Determined by Actigraph and Sleep Diary Over 8 Weeks. — 2249; 2304; 2319; 2325 HHMM.SS

Primary: Three Weeks of Cocaine Abstinence at End of Study — 9; 0 Participants

Primary: Number of Subjects With Clinical Global Impressions Scale - Improvement (CGI-I) Score of 1 or 2 — 6; 7 participants

Primary: Three Weeks of Continuous Cocaine Abstinence as Measured by Urine Toxicology and Self Report Based on Time Line Follow Back — 13; 7 participants — p==.05

Primary: The Number of Subjects in Each Treatment Group Exhibiting Sustained, 4-week Smoking Abstinence, Defined as CO Levels <= 4 Ppm for Each Post-quit Study Visit. — 5; 3…

Primary: Ratings of Job Application Quality — 3.40; 3.56 score on a scale

Primary: Systolic Blood Pressure — 116; 116; 126; 115 mmHg

Primary: Rule Violations During Direct Classroom Observation at Endpoint (Week 8) — 6.15; 4.93 number occurences per 30 mins — p=<.05

Primary: Mood State Score on POMS-2 Test — 2.63; 14.08; 2.19; 2.54 units on a scale

Primary: Lean Squares Mean (± Standard Error) of Math Test Score Over All Post-dose Time Points (0.5, 1, 2, 4, 8, 10, 12, 13, and 14 Hours Post-dose) Assessed During the…

Primary: Clean Urine Drug Screen — 13.1; 12.7 Clean urine drug screens

Primary: Change in Scores on the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire (MGH-CPFQ) — 27.5; 29; 22.6; 25 Scores on a scale

Primary: Change in Epworth Sleepiness Scale (ESS) Score — 5.0; 4.4 score on a scale

Primary: Average Number of Positive Urine Tests — 32; 30.2; 28.1; 31.4 urine tests

Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 0.06; 0.94; 0.75; 0.88 cocaine choices

Primary: Conners' Continuous Performance Test (CPT) (Double-blind Portion, Primary Variables) — -3.3; -3.58; -3.66; 0.19 Units — p=0.037

Primary: Cocaine Use as Assessed by the Treatment Effectiveness Score (TES), Which is the Total Number of Cocaine-negative Urines During Treatment — 9.25; 6.09; 6; 4.91 number of…

Primary: Time Till Relapse — 7; -8 Days to Relapse — p=<0.05

Primary: Non-displaceable Tracer Binding Potentials — 2.93; 2.91; 1.50; 1.50 ratio

Primary: Percentage of Participants With Methamphetamine-positive Urine Drug Screens — 85; 65 Percentage of participants

Primary: Number of High-effort Selections in the Effort-based Decision Making Task — 16.4; 21.35; 20.45; 19.8 Number of high-effort selections

Primary: Marijuana Abstinence — 0; 2 Participants

Primary: Conners' Adult ADHD Rating Scales-Self-Report: Short Version (CAARS-S:S, Conner et al, 1999) — 75.12; 68.56; 67.79; 72.80 units on a scale

Primary: Stop Signal Reaction Time (SSRT) as Derived From the Stop Signal Reaction Time Paradigm — 299.90; 308.82; 265.61; 260.51 milliseconds (msec) — p=0.504

Primary: Change in BRIEF-A — 21.38; 3.36 Scores on a scale — p=.005