N/A
Completed N=41
Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults
Source: ClinicalTrials.gov NCT03535844 ↗Enrolled (actual)
41
Serious AEs
0.0%
Results posted
Apr 2020
Primary outcomePrimary: Change in Lipidomic Profiles
Summary
This purpose of this study is to assess the impact of consuming wolfberry on cardiovascular risk in Singapore's middle-aged and older adults. The investigators hypothesize that consuming wolfberry with a healthy eating pattern diet will contribute to improvements in cardiovascular health when compared to a similar diet without wolfberry.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Lipidomic Profiles |
— | — |
| PRIMARY Change in Carotid Intima Media Thickness |
0.67; 0.60; 0.67; 0.70 | 0.49 |
| PRIMARY Change in Endothelial Progenitor Cells |
9.89; 10.36; 9.64; 9.46 | 0.67 |
| PRIMARY Change in Flow Mediated Dilation |
4.50; 3.95; 3.79; 5.34 | 0.08 |
| PRIMARY Change in Plasma Nitric Oxide |
15.91; 14.53; 19.38; 19.55 | 0.7162 |
| PRIMARY Change in Blood Carotenoid Status |
2020.9; 2746.3; 1916.2; 1682.9 | <0.05 sig |
| PRIMARY Change in Plasma Endothelin-1 |
1.31; 1.19; 1.11; 1.04 | 0.7052 |
| PRIMARY Change in Plasma ICAM-1 |
7.4; 7.1; 7.43; 7.14 | 0.9426 |
| SECONDARY Change in Blood Lipid-lipoprotein Concentrations |
1.18; 1.32; 1.15; 1.36; 5.16; 5.36 | 0.4855 |
| SECONDARY Change in Blood Pressure |
114; 106; 111; 107; 72; 69 | 0.1951 |
| SECONDARY Change in Oxidative Stress-related Biomarkers |
0.294; 0.327; 0.282; 0.316 | 0.9882 |
| SECONDARY Change in Body Composition |
36.5; 35.1; 36.2; 34.4 | 0.4408 |
| SECONDARY Change in Skin Carotenoid Status |
33636; 33713; 37879; 35426 | 0.1487 |
| SECONDARY Body Mass Index |
22.7; 22.8; 22.7; 22.9 | 0.9135 |
| SECONDARY Change in Waist Circumference |
80.5; 22.9; 80.4; 22.8 | 0.5859 |
| SECONDARY Change in Appetite |
215; 209; 194; 185 | 0.9379 |
| SECONDARY Dietary Carotenoids |
8627.1; 11087.4; 10487.8; 12845.98 | 0.9717 |
| SECONDARY Change in Sleep Quality |
— | — |
| SECONDARY Change in Cognitive Function |
— | — |
Eligibility Criteria
Inclusion Criteria
- Ability to give an informed consent
- Age 50 to 75 years
- Willing to follow the study procedures
Exclusion Criteria
- Significant change in weight (± 5% body weight) during the past 3 months
- Allergy to wolfberry
- Acute illness at the study baseline
- Exercising vigorously over the past 3 months
- Consistently following healthy eating pattern diet in the past 3 months
- Smoking
- Have an average weekly alcohol intake that above 21 units per week (males) and 14 units per week (females): 1 unit = 360 mL of beer; 150 mL of wine; 45 mL of distilled spirits)
- Pregnant, lactating, or planning pregnancy in the next 6 months
- Taking dietary supplements which may impact the outcome of interests (e.g. vitamin supplements, antioxidant supplement etc.)
- Prescribed and taking antihypertensive/cholesterol-lowering/ type-2 diabetic medication which started less than 5 years prior to the intervention participation
- Insufficient venous access to allow the blood collection
Data sourced from ClinicalTrials.gov (NCT03535844). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.