Evidence-Based Medical News

Mode

All Infectious Disease Oncology Neurology Cardiology Psychiatry Diabetes & Endocrinology Pediatrics Allergy & Immunology Rheumatology Gastroenterology Primary Care & Family Medicine Nutrition & Obesity Medicine Orthopedics & Sports Medicine OB/GYN & Women's Health Radiology & Imaging Genetics & Precision Medicine Pulmonology & Critical Care Anesthesiology & Pain Medicine Physical Medicine & Rehab Nephrology Hematology Urology Ophthalmology Dermatology Emergency Medicine Geriatrics & Aging ENT (Otolaryngology) Palliative Care

Research

Clinical Trials Drug Pipeline Weekly Digests

Reference

Conditions Medications

Community

Text Size

Log in / Sign up

Aging

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Aging

153 trials tracked for Aging: 10 in phase 3 or 4 and 3 with published results. The most-cited published study has 106 citations.

153Trials tracked

10Phase 3 & 4

0Recruiting

3With published results

Phase distribution

Phase 4 5 Phase 3 5 Phase 2 19 Phase 1 9 Other / NA 115

Phase 3 The LIFE Study - Lifestyle Interventions and Independence for Elders Completed · 106 cited
Phase 4 Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults Completed · 11 cited
Phase 4 Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines Completed · 4 cited
Phase 4 Metformin in Longevity Study (MILES). Completed
Phase 4 Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial Completed
Phase 4 Changing in Skin Physiology After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces Completed

Show 44 more trials

Phase 3 Cognition in the Study of Tamoxifen and Raloxifene Completed
Phase 3 A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes Completed
Phase 3 Subjects' Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure® and the Restylane® Range Completed
Phase 3 ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly Completed
Phase 2 Semaglutide Use in Elderly Obese Patients Completed
Phase 2 The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity Completed
Phase 2 Nutraceutical Effects on Long-Term Memory Completed
Phase 2 Resveratrol and Exercise to Treat Functional Limitations in Late Life Completed
Phase 2 The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial Completed
Phase 2 SGLT2 Inhibition in Older Obese Adults With Pre-diabetes Completed
Phase 2 Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age Completed
Phase 2 Acarbose Anti-aging Effects in Geriatric Subjects (Substudy B & C) Completed
Phase 2 Effects of Testosterone Gel on Carbohydrate and Lipid Metabolism In Elderly Obese Men Completed
Phase 2 Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease Completed
Phase 2 Executive Functioning Training Study Completed
Phase 2 Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly Completed
Phase 2 Evaluation of the Mechanism of Action of Platelet Rich Fibrin Matrix (PRFM) in Producing Skin Volume Augmentation Completed
Phase 2 Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease Completed
Phase 2 Pilot Study of Losartan and N-acetylcysteine as Inhibitors of Muscle Oxidative Stress in Elderly Completed
Phase 2 Efficacy of Polypodium Leucotomos Extract Decreasing UVA Premutagenic and Photoaging Markers Completed
Phase 2 ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension Completed
Phase 2 Postmenopausal Women Estrogen and Progesterone Infusion Completed
Phase 2 Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women Completed
Phase 1 Muscle Perfusion and Protein Metabolism in Elderly Completed
Phase 1 Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study Completed
Phase 1 Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion Completed
Phase 1 Spinal Excitation to Enhance Mobility Completed
Phase 1 Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock Completed
Phase 1 Metformin to Augment Strength Training Effective Response in Seniors (MASTERS) Completed
Phase 1 CONTROL Walking Study Completed
Phase 1 Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals Completed
Phase 1 A Trial of Habit Formation Theory for Exercise in Older Adults Completed
N/A Everyday Memory Intervention Completed
N/A Ambient Independence Measures for Guiding Care Transitions Completed
N/A Oral Hygiene in Assisted Living Completed
N/A PEU in Elderly TCU Residents Completed
N/A SimpleC Wellness Platform With Social Robot Interaction Completed
N/A ABSORB (Amount of Blueberries So Older Adults Reap Benefits) Completed
N/A A Needs-focused Palliative Care Intervention for Older Adults in ICUs Completed
N/A Psychosocial Intervention for Older HIV+ Adults With HAND Completed
N/A Effects of Gamma-tACS on Memory and Sleep Completed
N/A Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults Completed
N/A Exercise Effects on Word Learning Completed
N/A Cardiovascular Responses to Heat Waves in the Elderly Completed

Showing the 50 most-cited and recently-updated of 153 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Aging: what the trials found

Physical activity has been shown to significantly reduce the incidence of major mobility disability, specifically defined as the incapacity to walk 400 meters, and is associated with lower rates of persistent mobility disability over a 6-month assessment period ¹⁴.

Restylane Vital was found to improve skin hydration, elasticity, and melanin index ¹³.

Cognitive training did not result in statistically significant changes in memory, reasoning, or speed of processing over a 10-year period ¹⁸.

Recent results — preliminary, needs further review

OneClick Social Engagement Intervention significantly improved scores for social isolation, loneliness, and quality of life in patients with Alzheimer's disease ⁷.
Yakult 300 LIGHT Fermented Milk was associated with significant changes in gut microbiota and improvements in sarcopenia markers (handgrip strength and walking speed) ⁵.
Daily mouth care significantly reduced the Plaque Index Score for Long-Term Care over a 4-month period ³.
Nitrate-containing interventions were associated with changes in carotid artery compliance and carotid pulse pressure ².
Cannabis showed no statistically significant acute effects on mobility gait speed, balance (functional reach), or sustained attention ¹⁹.

For the clinician treating this condition

Physical activity is an established intervention to reduce major and persistent mobility disabilities in aging populations ¹⁴.
Social engagement interventions have shown significant improvements in loneliness and quality of life for patients with Alzheimer's disease ⁷.
Fermented milk (Yakult 300 LIGHT) may impact gut microbiota and improve physical markers associated with sarcopenia ⁵.

AI synthesis of 8 cited trials, updated Jun 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

1 2 Next ›

Questions about Aging

Do antioxidant strategies help male infertility in aging men with immune disorders?

Antioxidant strategies may help male infertility in aging men with immune disorders by reducing oxidative stress, but evidence is preliminary and personalized approaches are needed.

Full answer →

All Aging Articles