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Home › Conditions › Aging

Aging

9 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Aging

153 trials tracked for Aging: 10 in phase 3 or 4 and 3 with published results. The most-cited published study has 105 citations.

153Trials tracked
10Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 5 Phase 3 5 Phase 2 19 Phase 1 9 Other / NA 115
  1. Phase 3 The LIFE Study - Lifestyle Interventions and Independence for Elders Completed · 105 cited
  2. Phase 4 Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults Completed · 10 cited
  3. Phase 4 Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines Completed · 4 cited
  4. Phase 4 Metformin in Longevity Study (MILES). Completed
  5. Phase 4 Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial Completed
  6. Phase 4 Changing in Skin Physiology After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces Completed
Show 44 more trials
  1. Phase 3 Cognition in the Study of Tamoxifen and Raloxifene Completed
  2. Phase 3 A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes Completed
  3. Phase 3 Subjects' Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure® and the Restylane® Range Completed
  4. Phase 3 ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly Completed
  5. Phase 2 Semaglutide Use in Elderly Obese Patients Completed
  6. Phase 2 The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity Completed
  7. Phase 2 Nutraceutical Effects on Long-Term Memory Completed
  8. Phase 2 Resveratrol and Exercise to Treat Functional Limitations in Late Life Completed
  9. Phase 2 The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial Completed
  10. Phase 2 SGLT2 Inhibition in Older Obese Adults With Pre-diabetes Completed
  11. Phase 2 Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age Completed
  12. Phase 2 Acarbose Anti-aging Effects in Geriatric Subjects (Substudy B & C) Completed
  13. Phase 2 Effects of Testosterone Gel on Carbohydrate and Lipid Metabolism In Elderly Obese Men Completed
  14. Phase 2 Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease Completed
  15. Phase 2 Executive Functioning Training Study Completed
  16. Phase 2 Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly Completed
  17. Phase 2 Evaluation of the Mechanism of Action of Platelet Rich Fibrin Matrix (PRFM) in Producing Skin Volume Augmentation Completed
  18. Phase 2 Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease Completed
  19. Phase 2 Pilot Study of Losartan and N-acetylcysteine as Inhibitors of Muscle Oxidative Stress in Elderly Completed
  20. Phase 2 Efficacy of Polypodium Leucotomos Extract Decreasing UVA Premutagenic and Photoaging Markers Completed
  21. Phase 2 ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension Completed
  22. Phase 2 Postmenopausal Women Estrogen and Progesterone Infusion Completed
  23. Phase 2 Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women Completed
  24. Phase 1 Muscle Perfusion and Protein Metabolism in Elderly Completed
  25. Phase 1 Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study Completed
  26. Phase 1 Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion Completed
  27. Phase 1 Spinal Excitation to Enhance Mobility Completed
  28. Phase 1 Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock Completed
  29. Phase 1 Metformin to Augment Strength Training Effective Response in Seniors (MASTERS) Completed
  30. Phase 1 CONTROL Walking Study Completed
  31. Phase 1 Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals Completed
  32. Phase 1 A Trial of Habit Formation Theory for Exercise in Older Adults Completed
  33. N/A Everyday Memory Intervention Completed
  34. N/A Ambient Independence Measures for Guiding Care Transitions Completed
  35. N/A Oral Hygiene in Assisted Living Completed
  36. N/A PEU in Elderly TCU Residents Completed
  37. N/A SimpleC Wellness Platform With Social Robot Interaction Completed
  38. N/A ABSORB (Amount of Blueberries So Older Adults Reap Benefits) Completed
  39. N/A A Needs-focused Palliative Care Intervention for Older Adults in ICUs Completed
  40. N/A Psychosocial Intervention for Older HIV+ Adults With HAND Completed
  41. N/A Effects of Gamma-tACS on Memory and Sleep Completed
  42. N/A Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults Completed
  43. N/A Exercise Effects on Word Learning Completed
  44. N/A Cardiovascular Responses to Heat Waves in the Elderly Completed

Showing the 50 most-cited and recently-updated of 153 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review of community-based interventions for older adult independence
Primary Care & Family Medicine Meta-analysis
Systematic review of community-based interventions for older adult independence Community programs help older adults stay independent and active in their own homes
This systematic review of randomized controlled trials synthesized evidence on community-based public health interventions for community-dwe…
A review of many studies shows community health programs can improve independence and well-being for older adults living at home.
Frontiers May 21, 2026
Narrative review on BAT in older adults with obesity and exercise nutrition
Diabetes & Endocrinology Sys. Review
Narrative review on BAT in older adults with obesity and exercise nutrition Researchers find exercise and nutrition linked to fat burning in older adults with obesity
This narrative review synthesizes evidence on brown adipose tissue in older adults with obesity. It finds BAT volume and activity are reduce…
A review links exercise and nutrition to reduced fat-burning capacity in older adults with obesity, raising questions about how to support m…
Frontiers May 20, 2026
Systematic Review and Meta-Analysis Links α-Klotho to Frailty and Bone Health in Aging
Nephrology Meta-analysis
Systematic Review and Meta-Analysis Links α-Klotho to Frailty and Bone Health in Aging Higher Alpha-Klotho Levels Mean Less Frailty And Better Bones
This systematic review and meta-analysis of 109 studies found that higher circulating α-Klotho levels were associated with lower odds of fra…
New research shows that higher Alpha-Klotho levels protect against frailty and bone loss, offering hope for better aging outcomes.
Apr 30, 2026
GWAS and Mendelian randomization link aging, rheumatoid arthritis, and herpes zoster via shared MHC signals
Genetics & Precision Medicine
GWAS and Mendelian randomization link aging, rheumatoid arthritis, and herpes zoster via shared MHC signals Shared genetic link found for aging, arthritis, and shingles
This genomic analysis integrates genome-wide association studies, multi-omics quantitative trait loci, linkage disequilibrium-aware colocali…
A shared genetic signal may explain why aging, rheumatoid arthritis, and shingles often overlap.
medRxiv Apr 30, 2026
Narrative review discusses MEMR and MOCR recording techniques in aging adults with and without hearing loss
ENT (Otolaryngology)
Narrative review discusses MEMR and MOCR recording techniques in aging adults with and without hearing loss Ear Reflexes Could Spot Hearing Loss Before It Starts
This review examines recording methods for middle ear muscle reflex and medial olivocochlear reflex across different age and hearing groups.
New research on ear reflexes suggests they could reveal hidden hearing damage before standard hearing tests catch it.
medRxiv Apr 28, 2026
Systematic review of antioxidant and anti-inflammatory strategies for male infertility and immune-mediated testicular disorders
OB/GYN & Women's Health Sys. Review
Systematic review of antioxidant and anti-inflammatory strategies for male infertility and immune-mediated testicular disorders Sperm Health Tied to Immune System in New Way
This systematic review synthesizes evidence on targeted antioxidant and anti-inflammatory interventions for male infertility and related imm…
John and Maria tried for years to have a baby.
Frontiers Apr 22, 2026
Narrative review explores cytoskeleton-mediated autophagy regulation in neurodegeneration and aging
Allergy & Immunology Sys. Review
Narrative review explores cytoskeleton-mediated autophagy regulation in neurodegeneration and aging Review suggests cytoskeleton-autophagy axis may help treat neurodegeneration and aging
This narrative review examines the role of cytoskeleton-mediated autophagy regulation in the contexts of neurodegeneration and aging.
Targeting the cell's structural framework and cleanup system could offer new ways to treat neurodegeneration and aging.
Frontiers Apr 21, 2026
Resistance and interval training plus berry extract did not alter muscle AGEs in older adults
Physical Medicine & Rehab RCT
Resistance and interval training plus berry extract did not alter muscle AGEs in older adults Exercise and berries did not change AGE levels in muscle tissue of older adults
A 12-week RCT in 41 healthy adults aged 55-70 found that supervised resistance and high-intensity interval training, preceded by 30 days of…
Exercise and berry supplements did not lower advanced glycation end-products in the muscle tissue of healthy older adults in this study.
Apr 8, 2026
Systematic review examines nine therapeutic peptides for targeting aging hallmarks in older adults
Geriatrics & Aging Sys. Review
Systematic review examines nine therapeutic peptides for targeting aging hallmarks in older adults Can peptides help us age better? A review looks at nine promising compounds
A systematic review of 20 primary sources examined nine therapeutic peptides for healthy aging and age-related conditions in aging populatio…
Nine therapeutic peptides target aging biology, from restoring metabolism to protecting the brain, though experts warn more research is need…
Frontiers Apr 8, 2026

Questions about Aging

Do antioxidant strategies help male infertility in aging men with immune disorders?

Antioxidant strategies may help male infertility in aging men with immune disorders by reducing oxidative stress, but evidence is preliminary and personalized approaches are needed.

Full answer →