Phase 4 Completed N=26 Randomized Other

Improving Driving in Young People With Autism Spectrum Disorders

Autism Spectrum Disorder

Source: ClinicalTrials.gov NCT03538431 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Mar 2021

Primary outcomePrimary: Driving Performance - Measured by Mean Off-Road Glance Duration — 0.85; 0.90 Seconds

◆ Published Evidence

No publication linked

No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.

Summary

This study will examine the effects of treatment with the anti-anxiety medicine buspirone on driving performance (eye tracking) in individuals with high-functioning autism spectrum disorder (HF-ASD). The study consists of an Assessment Visit at Massachusetts General Hospital (MGH), as well as two Driving Simulation visits that will take place at Massachusetts Institute of Technology (MIT). Subjects will be given buspirone and asked to take the medication for the two days preceding the Driving Simulation Visit.

Outcome Measures

Outcome	Result	p-value
PRIMARY Driving Performance - Measured by Mean Off-Road Glance Duration	0.85; 0.90	—
PRIMARY Heart Rate	81.78; 82.74	—

Eligibility Criteria

Inclusion Criteria

Males and females, ages 18-24, with a diagnosis of DSM-V Autism Spectrum Disorder
Has a valid Driver's License

Exclusion Criteria

Major sensorimotor handicaps (e.g. deafness, blindness)
Individuals who have never held a valid driver's license
Intellectual Deficiency (Verbal Comprehension Index < 80)
Inadequate command of the English language
Subjects with any clinically meaningful medical or psychiatric condition as determined by the investigator
Individuals who are currently taking a monoamine oxidase inhibitor (MAOI) for any reason
Pregnant

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03538431). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.