N/A Completed N=97 Randomized Single-blind Basic Science

Hostile Interpretation Bias Training to Treat Irritability

Irritable Mood · Mood Disorders

Source: ClinicalTrials.gov NCT03592368 ↗

Enrolled (actual)

Serious AEs

1.0%

Results posted

Apr 2024

Primary outcomePrimary: Change in Interpretation Bias — 1.53; 0.55 units on a scale — p=<0.001

Summary

Hostile interpretation bias may be a feature of severe, chronic irritability in children, one of the most common psychiatric symptoms of childhood. Interpretation bias training (IBT) is a computer-based training program that may reduce irritability in youths. This trial lays the groundwork for a test IBT on irritability.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Interpretation Bias	1.53; 0.55	<0.001 sig
PRIMARY Neural Response in Threat Learning System.	16; 18	—
SECONDARY Learning Rate	0.019; 0.017	0.32
SECONDARY Irritability	-2.04; -1.44	0.12

Eligibility Criteria

Inclusion Criteria

Adolescents in mental health treatment, with at least:
mild, clinically significant irritability, and
typical intellectual functioning (IQ>80)

Exclusion Criteria

Any of the following mental health diagnoses:
current post-traumatic stress
lifetime bipolar I or II disorder
lifetime cyclothymic disorder
lifetime psychotic disorder
lifetime autism spectrum disorder
Major medical problems, including head trauma.
MRI-specific safety exclusions for the MRI arms.
Clinical instability.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03592368). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.