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Home › Conditions › Mood Disorders

Mood Disorders

Subtypes of Mood Disorders

Affective disorders 1

16 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Mood Disorders

37 trials tracked for Mood Disorders: 10 in phase 3 or 4 and 4 with published results. The most-cited published study has 20 citations.

37Trials tracked
10Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 4 Phase 3 6 Phase 2 6 Other / NA 21
  1. Phase 3 A Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Delphinus Trial Completed · 20 cited
  2. Phase 4 Stress & Premenstrual Symptoms Study Completed · 17 cited
  3. Phase 3 Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial) Completed · 13 cited
  4. Phase 3 Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress Completed · 7 cited
  5. Phase 4 Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation Completed
  6. Phase 4 A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth Completed
Show 31 more trials
  1. Phase 4 Effects of Epigallocatechin Gallate (EGCG) in Healthy, Young Adults Completed
  2. Phase 3 Study of the Safety and Efficacy of Fixed Dose OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Pyxis Trial) Completed
  3. Phase 3 Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial) Completed
  4. Phase 3 An Open-Label Trial Measuring Satisfaction And Convenience Of Two Formulations Of Lamotrigine In Subjects With A Mood Disorder Completed
  5. Phase 2 A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression Completed
  6. Phase 2 Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers Completed
  7. Phase 2 A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression Completed
  8. Phase 2 The Effects of Cannabidiol on the Driving Ability of Healthy Adults Completed
  9. Phase 2 Technology Enhanced Family Treatment Completed
  10. Phase 2 Rapid Antidepressant Effects of Ketamine in Major Depression Completed
  11. N/A SimpleC Wellness Platform With Social Robot Interaction Completed
  12. N/A Hostile Interpretation Bias Training to Treat Irritability Completed
  13. N/A Evaluating the Role of Expectations in Response to Caffeine Consumption: An RCT Completed
  14. N/A Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART) Completed
  15. N/A Polyunsaturated Fatty Acids (PUFA) Status and Cognitive Function in Healthy Young Adults Completed
  16. N/A Online Yoga for Individuals With Mood Disorders Completed
  17. N/A Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms Completed
  18. N/A One-Day Acceptance and Commitment Training Intervention in Primary Care Patients Completed
  19. N/A The Effects of Cranial Electrotherapy Stimulation (CES) on Brain Function, Brain Chemistry and Mood Completed
  20. N/A VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL Completed
  21. N/A Managing Cancer and Living Meaningfully Completed
  22. N/A The Impact of the COVID-19 (SARS-CoV-2 Disease) on Psychopathology Completed
  23. N/A Investigational Test of a New Sleep Supplement Completed
  24. N/A Mobile-enhanced Group CBT for Adolescents at Risk Severe Mood Disorders Completed
  25. N/A Efficacy of Sleep Interventions for Posttraumatic Stress Disorder (PTSD) Completed
  26. N/A Evaluating the Effects of Omega-3 Fatty Acids on Heart Disease and Behavior Completed
  27. N/A Reproductive Life Planning for Women With Mental Illness Completed
  28. N/A Transcranial Direct Current Stimulation Therapy for Bipolar Depression Completed
  29. N/A The Emotional, Physical and Cognitive Benefits of Purposeful Green Space Activities on Seniors Completed
  30. N/A Differential Effects of Clomiphene Citrate in Women Undergoing Superovulation Completed
  31. N/A Optimizing Cognitive Remediation Completed

Showing the 37 most-cited and recently-updated of 37 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Mood Disorders: what the trials found

New evidence indicates that open-label treatment with Omega-3 Fatty Acids and Inositol resulted in a mean reduction in the Parent-Young Mania Rating Scale (P-YMRS) score of -2.4 to -1.9 1.

Brexpiprazole demonstrated significant reductions in MADRS scores (-6.04, -4.86, or -4.57; p=0.0078), with further significant improvements observed at weeks 2 and 4 (p=0.0001) 8.

OPC-34712 showed statistically significant reductions in MADRS scores when administered alone (p=0.0074 for specific sub-populations) or in combination with ADT [10, 11]. Specifically, the addition of ADT to OPC-34712 resulted in significant MADRS improvements from week 8 to week 14 (p=0.0001) and a significant reduction in Sheehan Disability Scale (SDS) scores (p=0.0372) 12.

Ganaxolone demonstrated significant reductions in both the Hamilton Depression Rating Scale 17-item Version (HAMD17) and the Edinburgh Postnatal Depression Scale (EPDS) [15, 16].

Lamotrigine was associated with a reduction in Beck Depression Inventory (BDI-II) scores at week 3 (-1.7) 13.

EGCG administration did not result in significant modifications to mood or cognitive performance (p>0.05), though it did significantly modulate total hemoglobin levels (p<0.05) 7.

Recent results — preliminary, needs further review

  • BE-SMART-DR showed statistically significant results across multiple metrics, including Suicidal Ideation/Propensity (CHRT-SR: p=0.0008; SSI: p=<.0001) and Daily Rhythms via the Brief Social Rhythm Scale (p=0.0002) 2.
  • Transcranial Direct Current Stimulation (tDCS) showed clinical response in 34 participants at 6 weeks post-treatment 20.
  • The SimpleC Wellness Platform with Social Robot Interaction received high scores for technology acceptance 3.
  • Cognitive training resulted in a significant number of levels completed (p=0.009), though global cognitive scores and WHODAS 2.0 outcomes did not reach statistical significance 4.

For the clinician treating this condition

  • Pharmacological interventions including Brexpiprazole, Ganaxolone, and OPC-34712 (with or without ADT) have shown statistically significant improvements in established depression scales like MADRS and HAMD17.
  • Omega-3 Fatty Acids combined with Inositol showed a reduction in mania rating scores 1.
  • While EGCG significantly modulated hemoglobin levels, it did not show significant impact on mood or cognition 7.

AI synthesis of 9 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Hormonal contraceptive types influence mood outcomes with progestin-only methods showing higher risks for mood disorders
Psychiatry Sys. Review
Hormonal contraceptive types influence mood outcomes with progestin-only methods showing higher risks for mood disorders Hormonal Contraceptives Show Mixed Links to Depression and Anxiety
This narrative review examines the relationship between hormonal contraceptives and mental health outcomes in women of reproductive age. The…
New research shows that different types of hormonal birth control have varying effects on mood, anxiety, and depression in women.
Frontiers Jul 9, 2026
Mood disorders and benzodiazepine use increase risk for new persistent opioid use in postsurgical adults
Anesthesiology & Pain Medicine Meta-analysis
Mood disorders and benzodiazepine use increase risk for new persistent opioid use in postsurgical adults Mood Disorders and Anxiety Linked to Higher Risk of Opioid Use
This meta-analysis of retrospective cohort studies identifies that mood disorders, anxiety, Medicaid enrollment, and preoperative benzodiaze…
Patients with anxiety or mood disorders may face a higher risk of developing persistent opioid use after surgery.
Jul 5, 2026
Telehealth expansion during the COVID-19 pandemic partially disrupted mental health service utilization across all cohorts and age groups
Psychiatry Meta-analysis
Telehealth expansion during the COVID-19 pandemic partially disrupted mental health service utilization across all cohorts and age groups Mental health service use varies by condition during pandemic telehealth expansion
This meta-analysis examines mental health service utilization patterns in people ages 1–45 years with intellectual and developmental disabil…
Analysis of Medicaid claims shows mental health service use patterns differed by condition and age during the pandemic telehealth expansion.
Frontiers Jun 2, 2026
Review of dopamine receptor targeting for chronic pain and mood disorders notes limited causal evidence
Neurology Sys. Review
Review of dopamine receptor targeting for chronic pain and mood disorders notes limited causal evidence Treating dopamine receptors offers new hope for chronic pain and mood disorders
This narrative review examines the role of dopamine receptor system treatment in chronic pain and mood disorders. The authors synthesize fin…
Targeting dopamine receptors shows promise for managing chronic pain and mood issues, though more patient trials are needed to confirm benef…
Frontiers May 28, 2026
Semaglutide linked to lower neuropsychiatric event risk vs other diabetes drugs in observational study
Diabetes & Endocrinology Cohort
Semaglutide linked to lower neuropsychiatric event risk vs other diabetes drugs in observational study Semaglutide linked to lower neuropsychiatric risk than other diabetes drugs
This observational cohort study analyzed 63,215 patients with baseline neuropsychiatric conditions across a large US federated data platform…
A large observational study suggests semaglutide may be associated with a lower risk of neuropsychiatric conditions compared to other common…
medRxiv Apr 24, 2026
Scoping review of mental health in sub-Saharan African university students during COVID-19
Primary Care & Family Medicine Sys. Review
Scoping review of mental health in sub-Saharan African university students during COVID-19 Mental health crisis among African university students revealed
This systematic scoping review synthesized evidence on mental health among university students in sub-Saharan Africa during the COVID-19 pan…
Depression, anxiety, and suicidality are common among university students in sub-Saharan Africa, but help-seeking is rare. A new review maps…
Frontiers Apr 23, 2026
Paracingulate sulcus prevalence reduced in patients with catatonia compared to controls
Psychiatry Cohort
Paracingulate sulcus prevalence reduced in patients with catatonia compared to controls New Brain Scan Clue Points to Catatonia Risk
This hospital-based cohort study compared the paracingulate sulcus (PCS) in 109 patients with catatonia, 323 non-catatonic psychiatric patie…
A new study links specific brain shapes to catatonia, offering hope for better understanding.
medRxiv Apr 22, 2026
Case-control study links impaired decision-making tasks to suicide attempts in depressed patients
Psychiatry Case-Control
Case-control study links impaired decision-making tasks to suicide attempts in depressed patients Can't weigh risks and rewards? Suicide attempters show different decision-making patterns
This case-control study assessed 132 depressed patients with suicide attempts, patient controls, and healthy controls using clinical decisio…
People who attempted suicide weigh risks differently, showing less fear of loss and more impulsive errors that link directly to higher suici…
Frontiers Apr 19, 2026
Systematic review finds exercise prescription linked to mood, cognition, and stress resilience benefits
Psychiatry Sys. Review
Systematic review finds exercise prescription linked to mood, cognition, and stress resilience benefits Your Workout May Boost Mood Through Your Gut, Not Just Your Brain
A systematic review suggests exercise prescription is associated with advantageous impacts on mood, cognitive function, and stress resilienc…
Daily exercise may lift your mood by changing gut bacteria to produce mood-boosting molecules that signal your brain.
Frontiers Apr 15, 2026
Anti-inflammatory diets show mental health benefits in adults, with most consistent improvements in depressive symptoms
Psychiatry Meta-analysis
Anti-inflammatory diets show mental health benefits in adults, with most consistent improvements in depressive symptoms Anti-inflammatory diets may help improve depression symptoms in adults with mental health issues
A scoping review of 42 RCTs and 23 systematic evidence syntheses in adults found that anti-inflammatory dietary interventions, such as Medit…
Adults with depression saw better mental health outcomes when following anti-inflammatory diets like the Mediterranean or DASH plans compare…
Frontiers Apr 14, 2026
High-frequency rTMS plus exercise reduced craving and negative emotions in methamphetamine use disorder
Physical Medicine & Rehab RCT
High-frequency rTMS plus exercise reduced craving and negative emotions in methamphetamine use disorder Magnetic Pulses Plus Exercise Lift Mood in Meth Recovery
A randomized trial in 54 male patients with methamphetamine use disorder found that adding high-frequency rTMS to physical exercise reduced …
Pairing gentle magnetic brain pulses with regular exercise helped people in recovery feel better and want meth less.
Apr 13, 2026
Hypoxia-cognition training showed no significant effects on prefrontal or hippocampal microstructure in remitted mood disorder patients
Neurology RCT
Hypoxia-cognition training showed no significant effects on prefrontal or hippocampal microstructure in remitted mood disorder patients Hypoxia training did not change brain scans in remitted mood disorder patients
This randomized controlled trial evaluated 3 weeks of normobaric hypoxia combined with cognitive training versus treatment-as-usual in 57 pa…
Daily low-oxygen breathing exercises did not change brain scans in people with mood disorders who were already in remission.
Frontiers Apr 9, 2026

Questions about Mood Disorders

Does adding high-frequency rTMS and exercise reduce negative emotions in methamphetamine use disorder?

Yes, a 2024 trial found that adding high-frequency rTMS to exercise significantly reduced depression, anxiety, and craving in methamphetamine use disorder compared to exercise alone.

Full answer →

All Mood Disorders Articles