Phase 4
Completed N=1,409
Post-Discharge Smoking Cessation Strategies: Helping HAND 4
Source: ClinicalTrials.gov NCT03603496 ↗Enrolled (actual)
1,409
Serious AEs
—
Results posted
May 2022
Primary outcomePrimary: Tobacco Abstinence, Biochemically Confirmed — 110; 96 Participants — p=.19
◆ Published Evidence
Established
24citations · ~6 / year
Comparative Effectiveness of Postdischarge Smoking Cessation Interventions for Hospital Patients: The Helping HAND 4 Randomized Clinical Trial.
Summary
This randomized controlled trial will compare the effectiveness of two models of post-discharge tobacco cessation treatment for adult smokers admitted to 3 U.S. hospitals.
Linked Publications (3)
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Comparative Effectiveness of Postdischarge Smoking Cessation Interventions for Hospital Patients: The Helping HAND 4 Randomized Clinical Trial.
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Comparative effectiveness of post-discharge strategies for hospitalized smokers: Study protocol for the Helping HAND 4 randomized controlled trial.
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Can Treatment Support Mitigate Nicotine Metabolism-Based Disparities in Smoking Abstinence? Secondary Analysis of the Helping HAND 4 Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Tobacco Abstinence, Biochemically Confirmed |
110; 96 | .19 |
| SECONDARY Tobacco Abstinence, Self-report |
234; 202 | .079 |
| SECONDARY Engagement in Cessation Treatment |
434; 319 | <.0001 sig |
| SECONDARY Self-reported Continuous Tobacco Abstinence Since Hospital Discharge |
120; 91 | .033 sig |
Eligibility Criteria
Inclusion Criteria
- 18 years of age or older
- Current cigarette smoker (>=1 cigarette in the week before admission and >=1 cigarette/day when smoking at a baseline rate in the month prior to admission)
- Admitted to a study hospital
- Seen by hospital smoking counselor during inpatient stay
- Plans to try to quit smoking after hospital discharge
Exclusion Criteria
- Inability to give informed consent or participate in counseling due to serious cognitive or psychiatric disorder (e.g., dementia, psychosis)
- Life expectancy <12 months
- Medical instability
- No reliable telephone access or inability to use telephone
- Non-English speaking
- Pregnant, breastfeeding, to planning to become pregnant in the next 6 months.
Data sourced from ClinicalTrials.gov (NCT03603496) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.