N/A
N=19
Genetic Influences on Response to Gait Rehabilitation in Parkinson's Disease
Parkinson's Disease
Bottom Line
View on ClinicalTrials.gov: NCT03607695 ↗Enrolled (actual)
19
Serious AEs
0.0%
Results posted
Oct 2021
Primary outcome: Primary: Gait Speed (m/s) — 1.14; 1.21; 1.22; 1.20 m/s
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Gait training (Other)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Jun 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Gait Speed (m/s) |
1.14; 1.21; 1.22; 1.20 | — |
| PRIMARY Montreal Cognitive Assessment Score |
27.1; 27.7 | — |
Summary
The aging Veteran population, together with high exposure to Agent Orange or other herbicides during military service, has made diseases such as Parkinson's disease (PD), currently affecting more than 80,000 Veterans, a major health issue in the Veterans' health system. Mobility and cognitive limitations are a common problem in PD and are associated with significant disability, increased fall risk, reduced quality of life, and increased caregiver burden. While less is known about its benefit on cognition, physical therapy has proven to be an effective treatment to mitigate mobility limitations, though the response to rehabilitation interventions is highly variable. The proposed research will inform the investigators' understanding of the impact of certain genetic profiles associated with learning impairments on motor and cognitive benefits in response to gait rehabilitation, and will provide an important foundation for more personalized and improved gait rehabilitation programs for different subgroups of PD patients.
Eligibility Criteria
Inclusion Criteria
- Meet UK Brain Bank (UKBB) criteria for the diagnosis of PD (modified so that having more than one affected relative was not considered an exclusion criteria)
- Have a Hoehn & Yahr score of 3
- Have the ability to walk 400 m without physical assistance from a device or another person
- Do not have other health conditions (e.g., orthopedic, cardiopulmonary) that impact the ability to safely participate in a moderately intense gait training program
Exclusion Criteria
- The investigators will exclude those patients presenting clinical diagnosis of dementia.
- The investigators will exclude those patients presenting conditions (cardiac, renal, or metabolic) that would pose a risk to their health by exercising.
Data sourced from ClinicalTrials.gov (NCT03607695). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.