N/A
N=254
PRediction of Acute Coronary Syndrome in Acute Ischemic StrokE
Stroke, Ischemic · Acute Coronary Syndrome
Bottom Line
View on ClinicalTrials.gov: NCT03609385 ↗Enrolled (actual)
254
Serious AEs
2.8%
Results posted
Mar 2025
Primary outcome: Primary: Presence of Myocardial Infarction — 126; 121 Participants
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- Coronary angiography (Diagnostic_test)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Charite University, Berlin, Germany
- Primary completion
- Dec 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Presence of Myocardial Infarction |
126; 121 | — |
| SECONDARY Mortality |
39; 208 | — |
| SECONDARY Functional Outcome |
66; 35; 23; 25; 21; 4 | — |
| SECONDARY Cardiovascular Events |
60 | — |
Summary
The primary goal of the PRAISE study is to develop a diagnostic algorithm that allows the prediction of acute coronary syndrome in stroke patients with elevated levels of cardiac troponin.
Eligibility Criteria
Inclusion Criteria
- diagnosis of ischemic stroke based on clinical and imaging information (CT or MRI)
- diagnosis of transient ischemic attack if the initial focal neurological deficit has been examined by a neurologist and if the ABCD2-score is ≥ 4
- Elevation of high-sensitive cardiac troponins according to the rule-in/rule-out algorithm of the 2015 ESC guidelines for NSTE-ACS, i.e. highly abnormal troponin at 0 hours (> 52ng/l if hs-cTnT, Elecsys-Assay, or > 52ng/l, if hs-cTnI; Architect-Assay, or > 107 ng/l, if hs-cTnI. Dimension Vista Assay) or dynamic change > 20% of the initial value at re-test after 3 hours with at least one value above the 99th percentile of a healthy reference population
- ability to give informed consent
- onset of symptoms 100 ml (either on Diffusion Weighted Imaging on cMRI or on CT if CT is performed > 24 hours after onset) or ASPECTS score 3)
- pregnancy or breast-feeding
- limited life expectancy 72 hours after hospital admission
Data sourced from ClinicalTrials.gov (NCT03609385). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.