N/A
N=80
The Impacts of Theta-burst Stimulation on Children and Adolescents With Autism Spectrum Disorder
Autism Spectrum Disorder
Bottom Line
View on ClinicalTrials.gov: NCT03621189 ↗Enrolled (actual)
80
Serious AEs
0.0%
Results posted
Aug 2021
Primary outcome: Primary: Changes of Total Scores of Social Responsiveness Scale — 107.3; 102.1; 103.4; 100.1 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- intermittent theta burst stimulation (Device)
- Age
- Pediatric, Adult · 7+ yrs
- Sex
- All
- Sponsor
- Chang Gung Memorial Hospital
- Primary completion
- Apr 2019
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes of Total Scores of Social Responsiveness Scale |
107.3; 102.1; 103.4; 100.1; 98.5; 95.1 | — |
| PRIMARY Changes of Total Scores of Repetitive Behavior Scale-Revised |
32.2; 33.5; 28.9; 28.1; 25.9; 31.5 | — |
| SECONDARY Changes in Accuracy of Frith-Happe Animation |
5.5; 5.6; 5.4; 5.7; 5.4; 5.4 | — |
| SECONDARY Changes in Accuracy of Eyes Task |
20.8; 24.8; 21.9; 25.8; 21.8; 24.8 | — |
| SECONDARY Functional MRI (Biological Motion Task) |
— | — |
| SECONDARY Resting State fMRI |
— | — |
| SECONDARY Diffusion Tensor Imaging |
— | — |
Summary
The investigator would like to investigate the impact of theta-burst stimulation over posterior superior temporal sulcus in children and adolescents with autism spectrum disorder
Eligibility Criteria
Inclusion Criteria
- autism spectrum disorder, confirmed by ADOS
Exclusion Criteria
- current and past systemic disease
- current and past major psychiatric disorders including schizophrenia, bipolar affective disorder and major depressive disorder
- current and past brain injuries
- intelligence < 70
- seizure history
- pregnant
Data sourced from ClinicalTrials.gov (NCT03621189). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.