N/A
N=63
Effect of Mental Imagery Training on Brain Plasticity and Motor Function in Individuals With Parkinson's Disease
Parkinson Disease
Bottom Line
View on ClinicalTrials.gov: NCT03623386 ↗Enrolled (actual)
63
Serious AEs
0.0%
Results posted
Sep 2023
Primary outcome: Primary: Change in Right Insula-dorsomedial Frontal Cortex Functional Connectivity Strength. — 93.2; 97.8 percent change from baseline — p=0.981
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- PD neurofeedback (Other); PD control (Other)
- Age
- Adult, Older Adult · 40+ yrs
- Sex
- All
- Sponsor
- Yale University
- Primary completion
- Sep 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Right Insula-dorsomedial Frontal Cortex Functional Connectivity Strength. |
93.2; 97.8 | 0.981 |
| PRIMARY Change in Resting-state Functional Connectivity Between the Right Insula and Dorsomedial Frontal Cortex. |
-2.9; 74.2 | 0.481 |
| PRIMARY Change in Motor Impairment |
32.3; 34.5; 31.3; 35.1 | >0.05 |
| PRIMARY Change in Motor Function |
23.7; 24.4; 22.3; 24.1 | 0.026 sig |
Summary
Effect of Mental Imagery Training on Brain Plasticity and Motor Function in Individuals with Parkinson's Disease: A functional MRI investigation.
Eligibility Criteria
Inclusion Criteria
- Subjects with a diagnosis of idiopathic PD defined according to the UK Brain Bank diagnostic criteria and on a stable dopaminergic medication regimen will be included.
Exclusion Criteria
- Age 7 drinks per week for women, > 14 drinks per week for men) or substance use
- History of a neurological disorder such as a brain tumor, stroke, central nervous system infection, multiple sclerosis, movement disorder (other than PD), or seizures
- History of schizophrenia, bipolar disorder, attention deficit disorder, or obsessive compulsive disorder
- History of head injury with loss of consciousness
- Metallic surgical implants or traumatically implanted metallic foreign bodies
- Inability to lie flat for about an hour
- Discomfort being in small, enclosed spaces
- Dementia (Montreal Cognitive Assessment score 19)
- Hoehn & Yahr stage > 3 (i.e., able to stand and walk, but not fully independent)
- Focal neurological findings on exam that suggest cerebral pathology other than that associated with parkinsonism
- Motor symptoms that could potentially introduce too much motion artifact in the imaging data (e.g., MDS-UPDRS resting tremor score > 1 in limbs, head/chin tremor, or dyskinesia by history or exam).
Data sourced from ClinicalTrials.gov (NCT03623386). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.