N/A
Completed N=113
MiACLR: Michigan Initiative for Anterior Cruciate Ligament Rehabilitation
Source: ClinicalTrials.gov NCT03626857 ↗Enrolled (actual)
113
Serious AEs
12.4%
Results posted
Jan 2026
Primary outcomePrimary: Immediately Post NMES+ECC Intervention Isokinetic Quadriceps Strength Index — 60.9; 58.4 Percentage — p=.025
Summary
This clinical trial evaluates interventions to maximize muscle function and improve cartilage health following anterior cruciate ligament reconstruction. Improving muscle function may improve patient outcomes, improve joint mechanics, and potentially serve as a prevention approach for post-traumatic knee osteoarthritis. Knee osteoarthritis (OA) is a disabling disease that carries a substantial burden to society and to the individual affected.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Immediately Post NMES+ECC Intervention Isokinetic Quadriceps Strength Index |
60.9; 58.4 | .025 sig |
| PRIMARY 9 Months Isokinetic Quadriceps Strength Limb Symmetry Index |
76.8; 74.5 | 0.025 sig |
| SECONDARY Knee Flexion Angle at 9 Months |
50.9; 44.4 | — |
| SECONDARY Knee Flexion Moment at 9 Months |
1.4; 1.3 | — |
| SECONDARY Knee Flexion Angle at 18 Months |
53.4; 48.8 | — |
| SECONDARY Knee Flexion Moment at 18 Months |
1.5; 1.5 | — |
| SECONDARY T1 Rho Relaxation Time Symmetry Score for Femoral Knee Joint Cartilage |
103.0; 106.1 | — |
| SECONDARY T2 Relaxation Time Symmetry Score for Femoral Knee Joint Cartilage |
101.3; 104.4 | — |
Eligibility Criteria
Inclusion Criteria
- Acute, complete ACL rupture
- ACL reconstruction with autograft
- Scheduled to undergo ACLR at U of Michigan
- Willingness to participate in testing and follow-up as outlined
Exclusion Criteria
- Previous surgery to either knee
- Bony fracture accompanying ACL injury
- Patients who experienced a knee dislocation
- Female participants who are pregnant or planning pregnancy
Data sourced from ClinicalTrials.gov (NCT03626857). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.