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Home › Conditions › anterior cruciate ligament injury

Anterior cruciate ligament injury

Part of Knee Injuries

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for anterior cruciate ligament injury

11 trials tracked for anterior cruciate ligament injury: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 51 citations.

11Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Other / NA 8
  1. Phase 4 Clinical Comparison of Femoral Nerve Versus Adductor Canal Block Following Anterior Ligament Reconstruction Completed · 51 cited
  2. Phase 4 A Novel Analgesia Technique for ACL Reconstruction Completed
  3. Phase 3 Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction Completed
  4. N/A Electrical Stimulation and Eccentric Exercise for Anterior Cruciate Ligament (ACL) Injury Completed
  5. N/A Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction Completed
  6. N/A Acupuncture ACL (Anterior Cruciate Ligament) Completed
Show 5 more trials
  1. N/A Bone Tunnel Widening Following ACL Reconstruction Completed
  2. N/A Functional Resistance Training to Improve Knee Function After ACL Reconstruction Completed
  3. N/A Reduction of Risk Factors for ACL Re-injuries Using a Novel Biofeedback Approach Completed
  4. N/A MiACLR: Michigan Initiative for Anterior Cruciate Ligament Rehabilitation Completed
  5. N/A MDR EZ Pass and Precision Flexible Reamer Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Anterior cruciate ligament injury: what the trials found

Celecoxib has been shown to significantly reduce pain levels as measured by the Visual Analog Scale (2.5 vs. 4.06, p<0.001) and improve Patient-Reported Outcomes Measurement Information System scores (61.4 vs. 66.3, p<0.001) in patients with anterior cruciate ligament injury 1.

Clinical evidence includes the use of 0.2% ropivacaine 3 and bupivacaine 4 as interventions for this condition.

Recent results — preliminary, needs further review

  • Neuromuscular Electrical Stimulation (NMES) combined with eccentric exercise showed a significant increase in Isokinetic Quadriceps Strength Index immediately post-intervention (60.9 vs. 58.4, p=0.025) and at 9 months (76.8 vs. 74.5, p=0.025). At 9 months, the knee flexion angle was recorded at 50.9 for the intervention group compared to 44.4 in the control 2.
  • The use of an EZ Pass Suture Passer has been evaluated as a recent intervention 5.

For the clinician treating this condition

  • Celecoxib is associated with statistically significant improvements in both patient-reported outcomes and visual analog scale pain scores 1.
  • Neuromuscular Electrical Stimulation (NMES) combined with eccentric exercise may improve quadriceps strength at both immediate and 9-month follow-ups 2.

AI synthesis of 5 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Machine learning and markerless gait analysis show high predictive accuracy for return-to-sport readiness and re-injury risk
Orthopedics & Sports Medicine Meta-analysis
Machine learning and markerless gait analysis show high predictive accuracy for return-to-sport readiness and re-injury risk Machine Learning Helps Predict Return to Sport After ACL Injury
This meta-analysis evaluates the use of machine learning and markerless gait analysis in patients with lower extremity injuries. Wearable se…
New technology using wearable sensors and motion analysis can help predict when athletes are ready to return to sports after a ligament inju…
Frontiers Jun 17, 2026
Neuromuscular training reduces ACL injury risk in athletes: meta-analysis
Primary Care & Family Medicine Meta-analysis
Neuromuscular training reduces ACL injury risk in athletes: meta-analysis Neuromuscular training cuts ACL injury risk in athletes
This systematic review and meta-analysis of 19 studies found that neuromuscular training significantly reduces the risk of ACL injury in ath…
A new analysis of 19 studies finds that neuromuscular training can cut the risk of ACL injuries in athletes by more than half.
Frontiers May 26, 2026

Research across Knee Injuries

Related studies from across the Knee Injuries family.

Suture tape augmentation improves time-zero stability in primary anterior cruciate ligament repairs
Cardiology Sys. Review
Suture tape augmentation improves time-zero stability in primary anterior cruciate ligament repairs Suture Tape Augmentation May Improve Stability in ACL Tear Repairs
This narrative review examines the use of suture tape augmentation for primary anterior cruciate ligament repairs. The authors conclude that…
Suture tape augmentation can improve immediate stability in ACL repairs, but its long-term success varies greatly depending on the patient's…
Frontiers Sep 17, 2026