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Home › Conditions › anterior cruciate ligament injury

Anterior cruciate ligament injury

Part of Knee Injuries

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for anterior cruciate ligament injury

11 trials tracked for anterior cruciate ligament injury: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 48 citations.

11Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Other / NA 8
  1. Phase 4 Clinical Comparison of Femoral Nerve Versus Adductor Canal Block Following Anterior Ligament Reconstruction Completed · 48 cited
  2. Phase 4 A Novel Analgesia Technique for ACL Reconstruction Completed
  3. Phase 3 Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction Completed
  4. N/A Electrical Stimulation and Eccentric Exercise for Anterior Cruciate Ligament (ACL) Injury Completed
  5. N/A Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction Completed
  6. N/A Acupuncture ACL (Anterior Cruciate Ligament) Completed
Show 5 more trials
  1. N/A Bone Tunnel Widening Following ACL Reconstruction Completed
  2. N/A Functional Resistance Training to Improve Knee Function After ACL Reconstruction Completed
  3. N/A Reduction of Risk Factors for ACL Re-injuries Using a Novel Biofeedback Approach Completed
  4. N/A MiACLR: Michigan Initiative for Anterior Cruciate Ligament Rehabilitation Completed
  5. N/A MDR EZ Pass and Precision Flexible Reamer Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Anterior cruciate ligament injury: what the trials found

Celecoxib has been shown to significantly reduce pain levels as measured by the Visual Analog Scale (2.5 vs. 4.06, p<0.001) and improve Patient-Reported Outcomes Measurement Information System scores (61.4 vs. 66.3, p<0.001) in patients with anterior cruciate ligament injury 1.

Clinical evidence includes the use of 0.2% ropivacaine 3 and bupivacaine 4 as interventions for this condition.

Recent results — preliminary, needs further review

  • Neuromuscular Electrical Stimulation (NMES) combined with eccentric exercise showed a significant increase in Isokinetic Quadriceps Strength Index immediately post-intervention (60.9 vs. 58.4, p=0.025) and at 9 months (76.8 vs. 74.5, p=0.025). At 9 months, the knee flexion angle was recorded at 50.9 for the intervention group compared to 44.4 in the control 2.
  • The use of an EZ Pass Suture Passer has been evaluated as a recent intervention 5.

For the clinician treating this condition

  • Celecoxib is associated with statistically significant improvements in both patient-reported outcomes and visual analog scale pain scores 1.
  • Neuromuscular Electrical Stimulation (NMES) combined with eccentric exercise may improve quadriceps strength at both immediate and 9-month follow-ups 2.

AI synthesis of 5 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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Primary Care & Family Medicine Meta-analysis
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A new analysis of 19 studies finds that neuromuscular training can cut the risk of ACL injuries in athletes by more than half.
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