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Phase 4 Completed N=31 Randomized Triple-blind Treatment

Pain Outcomes Following Intralesional Corticosteroid Injections

Keloid · Alopecia Areata · acne · Hypertrophic Scar
Source: ClinicalTrials.gov NCT03630198 ↗
Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Mar 2021
Primary outcomePrimary: Pain Outcome: Visual Analog Scale — 5.4; 2.7 Score on a scale
◆ Published Evidence
Emerging
9citations · ~2 / year
Intralesional corticosteroid injections are less painful without local anesthetic: a double-blind, randomized controlled trial.
The Journal of dermatological treatment · 2022 · Likely link

Summary

Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics. However, these injections can be quite painful, which leads many patients to discontinue treatment. Often, the injection involves a mixture of local anesthetic and corticosteroids despite a lack of evidence that the use of lidocaine improves pain. Due to the acidic pH, the lidocaine component of the injection can actually cause a significant burning sensation during the procedure. Lidocaine does not have anti-inflammatory properties and does not treat the underlying pathology. By including another medication, lidocaine also adds cost and risk to the procedure. The purpose of this study is to see if removing lidocaine from intralesional injections decreases the pain of injection.

Linked Publications

  • Intralesional corticosteroid injections are less painful without local anesthetic: a double-blind, randomized controlled trial.
    The Journal of dermatological treatment · 2022 · 9 citations · Likely link

Outcome Measures

OutcomeResultp-value
PRIMARY
Pain Outcome: Visual Analog Scale
0.9; 0.1; 0; 0

Eligibility Criteria

Inclusion Criteria

  • >12 years old presenting with an indication for intralesional steroid injection

Exclusion Criteria

  • Unconsentable
  • Not a candidate for corticosteroid injection
  • Contraindication to lidocaine
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03630198) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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