N/A N=26 Treatment

Transcranial Direct Current Stimulation Therapy for Major Depression

Major Depressive Disorder

Bottom Line

View on ClinicalTrials.gov: NCT03632434 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2024

Primary outcome: Primary: Clinical Response — 22 Participants

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: transcranial direct current stimulation (Device)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of East London
Primary completion: Nov 2021

Outcome Measures

Outcome	Result	p-value
PRIMARY Clinical Response	22	—

Summary

Depression is a prevalent and debilitating disorder. The most common treatments are antidepressant medications and talking therapies. However, for many individuals, these are not their treatment of choice. Furthermore, even following a full course of treatment with an antidepressant or talking therapy, over one third of patients continue to be unwell. The novel brain stimulation treatment, transcranial direct current stimulation (tDCS), is a potential first-line treatment for major depression. The present research question is whether tDCS can be provided as a home-based treatment for major depression for adults with major depression.

Eligibility Criteria

Inclusion Criteria

diagnosis of major depressive disorder based on DSM-5 criteria
minimum score of 16 on Hamilton Rating Scale for Depression (HAM-D)

Exclusion Criteria

history of treatment-resistant depression
comorbid psychiatric disorder
significant risk of suicide or self harm
any contraindications to tDCS, including implanted electronic medical devices

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03632434). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.