Phase 1
Completed N=42
Effects of E-cigarette Flavors on Youth TCORS 2.0
Source: ClinicalTrials.gov NCT03634839 ↗Enrolled (actual)
42
Serious AEs
0.0%
Results posted
Aug 2024
Primary outcomePrimary: Liking: Difference Score in Liking/Wanting of Each E-cigarette Condition — 1.268; -3.916 score on a scale — p=0.053
Summary
This study is an examination of the influence of sweet and cooling flavors on the appeal and abuse potential of nicotine-containing e-cigarettes among susceptible youth.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Liking: Difference Score in Liking/Wanting of Each E-cigarette Condition |
1.268; -3.916 | 0.053 |
| PRIMARY Reinforcing Efficacy: Difference Score in Drug Effects of Each E-cigarette Condition |
37.06; 35.18 | 0.187 |
| PRIMARY Craving: Change in Craving Score for E-cigarette |
2.72; 2.43 | 0.135 |
| PRIMARY Irritation/Harshness: Difference Score in Irritation of Harshness of Each E-cigarette Condition |
20.92; 22.86 | 0.210 |
Eligibility Criteria
Inclusion Criteria
- Ages 18-20 years
- Able to read and write
- Used e-cigs at least 10 times in lifetime
- Used e-cigs in past 30 days
Exclusion Criteria
- Current use of non-prescription substances besides nicotine, marijuana, alcohol
- Any significant current medical or psychiatric condition
- Known hypersensitivity to propylene glycol
- Pregnant or lactating females
- Uncontrolled asthma
- Nut/e-liquid flavorant allergy
- current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI) symptoms
Data sourced from ClinicalTrials.gov (NCT03634839). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.