Phase 1
N=130
Effects of E-Cigarette Flavors on Adults TCORS 2.0
Nicotine Use Disorder
Bottom Line
View on ClinicalTrials.gov: NCT03635333 ↗Enrolled (actual)
130
Serious AEs
0.0%
Results posted
Dec 2025
Primary outcome: Primary: Change Score in Liking/Wanting of E-cigarette — -1.06; -5.59; -7.14; -7.63 units on scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 1
- Interventions
- Nicotine (Drug); Flavor (Drug)
- Age
- Adult · 21+ yrs
- Sex
- All
- Sponsor
- Yale University
- Primary completion
- Jul 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change Score in Liking/Wanting of E-cigarette |
-1.06; -5.59; -7.14; -7.63; 8.41; 0.42 | — |
Summary
This study looks at the effects of flavors when administered with nicotine in e-cigarettes in younger and older adult cigarette smokers.
Eligibility Criteria
Inclusion Criteria
- Ages 21-34 years or 35 -50 years
- Able to read and write
- Smoking >/= 1 cigarettes or cigars/day
- Willing to abstain from regular smoking for 2 weeks and use only e-cigarettes
- Not seeking treatment to stop smoking
Exclusion Criteria
- Daily use of other drugs including prescribed psychoactive drugs
- Any significant current medical or psychiatric condition
- Known hypersensitivity to propylene glycol
- Pregnant or lactating females
Data sourced from ClinicalTrials.gov (NCT03635333). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.