N/A N=38

Age-related Hearing Loss and Lexical Disorders

Alzheimer Disease · Presbycusis · Lexical Syntactic Disorder

Bottom Line

View on ClinicalTrials.gov: NCT03638323 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Sep 2019

Primary outcome: Primary: Link Between Lack of Word and Presbycusis — 38; 38.5; 23; 21.5 score on a scale

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: Speech therapy (Other)
Age: Older Adult · 65+ yrs
Sex: All
Sponsor: Groupe Hospitalier de la Rochelle Ré Aunis
Primary completion: Jan 2019

Outcome Measures

Outcome	Result	p-value
PRIMARY Link Between Lack of Word and Presbycusis	38; 38.5; 23; 21.5; 15; 17	—
SECONDARY Association Between Age and Lack of Word	76; 80	—
SECONDARY Association Between Gender and Lack of Word	7; 18; 9; 3	—
SECONDARY Association Between Study Level and Lack of Word	6; 17; 10; 4	—
SECONDARY Association Between Accommodation Type and Lack of Word	15; 21; 1; 0	—
SECONDARY Association Between Laterality and Lack of Word	16; 18; 0; 3	—
SECONDARY Association Between Main Diagnosis and Lack of Word	3; 7; 13; 14	—
SECONDARY Association Between Hearing Aid and Lack of Word	0; 3; 16; 18	—
SECONDARY Association Between Speech Therapy and Lack of Word	5; 5; 11; 16	—

Summary

In France, Alzheimer's disease accounts for 70 to 80% of the causes of neurocognitive disorders, i.e. 600,000 to 800,000 patients. It is a neurodegenerative pathology that causes evolutionary cognitive dysfunction, mainly affecting memory functions. The inability to name familiar objects (lack of the word) is one of the most commonly noted symptoms at an early stage of the disease. Presbyacusis, or age-related hearing loss, is the most common sensory deficit in the elderly which is manifested socially by a progressive discomfort of verbal communication. Presbyacusis remains underdiagnosed and undertreated: 2/3 of the patients are not using hearing aid. In recent years, a link between neurocognitive disorders and hearing loss has been shown by investigating general cognition. In this study, the investigators are investigating lexical disorders.

Eligibility Criteria

Inclusion Criteria

> 65 years old
French mother tongue
Good vision with or without correction
Alzheimer's or related disease (15 <Mini-Mental State Examination<25)
Affiliate or beneficiary of a social security
Informed consent

Exclusion Criteria

Cognitive disorders related to another pathology (cerebrovascular accident, head trauma, epilepsy ...)
Protected patient (under guardianship) or person deprived of liberty by judicial or administrative decision

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03638323). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.