N/A
Completed N=38
Age-related Hearing Loss and Lexical Disorders
Alzheimer's Disease · Presbycusis · Lexical Syntactic Disorder
Source: ClinicalTrials.gov NCT03638323 ↗
Enrolled (actual)
38
Serious AEs
0.0%
Results posted
Sep 2019
Primary outcomePrimary: Link Between Lack of Word and Presbycusis — 38; 38.5; 23; 21.5 score on a scale
Summary
In France, Alzheimer's disease accounts for 70 to 80% of the causes of neurocognitive disorders, i.e. 600,000 to 800,000 patients. It is a neurodegenerative pathology that causes evolutionary cognitive dysfunction, mainly affecting memory functions. The inability to name familiar objects (lack of the word) is one of the most commonly noted symptoms at an early stage of the disease.
Presbyacusis, or age-related hearing loss, is the most common sensory deficit in the elderly which is manifested socially by a progressive discomfort of verbal communication. Presbyacusis remains underdiagnosed and undertreated: 2/3 of the patients are not using hearing aid.
In recent years, a link between neurocognitive disorders and hearing loss has been shown by investigating general cognition. In this study, the investigators are investigating lexical disorders.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Link Between Lack of Word and Presbycusis |
38; 38.5; 23; 21.5; 15; 17 | — |
| SECONDARY Association Between Age and Lack of Word |
76; 80 | — |
| SECONDARY Association Between Gender and Lack of Word |
7; 18; 9; 3 | — |
| SECONDARY Association Between Study Level and Lack of Word |
6; 17; 10; 4 | — |
| SECONDARY Association Between Accommodation Type and Lack of Word |
15; 21; 1; 0 | — |
| SECONDARY Association Between Laterality and Lack of Word |
16; 18; 0; 3 | — |
| SECONDARY Association Between Main Diagnosis and Lack of Word |
3; 7; 13; 14 | — |
| SECONDARY Association Between Hearing Aid and Lack of Word |
0; 3; 16; 18 | — |
| SECONDARY Association Between Speech Therapy and Lack of Word |
5; 5; 11; 16 | — |
Eligibility Criteria
Inclusion Criteria
- > 65 years old
- French mother tongue
- Good vision with or without correction
- Alzheimer's or related disease (15 <Mini-Mental State Examination<25)
- Affiliate or beneficiary of a social security
- Informed consent
Exclusion Criteria
- Cognitive disorders related to another pathology (cerebrovascular accident, head trauma, epilepsy ...)
- Protected patient (under guardianship) or person deprived of liberty by judicial or administrative decision
Data sourced from ClinicalTrials.gov (NCT03638323). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.