Phase 3
Completed N=30
Vaginal Preparation With Chlorhexidine-alcohol vs. Povidine-iodine vs. Saline
Cesarean Section; Infection · Surgical Site Infection
Source: ClinicalTrials.gov NCT03640507 ↗
Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Jun 2020
Primary outcomePrimary: Post-intervention Aerobic Bacterial Colony Counts — 2.959; 0.945; 5.104 Log (CFU/mL)
◆ Published Evidence
Established
65citations · ~11 / year
Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections.
Summary
The purpose of this study is to see whether chlorhexidine is superior to povidine-iodine vaginal antisepsis at reducing bacteria colony counts in pregnant women by comparing three groups: vaginal washing with chlorhexidine-alcohol, vaginal washing with povidine-iodine, and vaginal washing with saline alone.
Linked Publications (2)
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Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections.
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A randomized trial of the bactericidal effects of chlorhexidine vs povidone-iodine vaginal preparation.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Post-intervention Aerobic Bacterial Colony Counts |
2.959; 0.945; 5.104 | — |
| PRIMARY Post-intervention Anaerobic Bacterial Colony Counts |
4.934; 2.637; 5.804 | — |
| SECONDARY Baseline Aerobic Bacterial Colony Counts |
5.942; 5.667; 6.480 | — |
| SECONDARY Baseline Anaerobic Bacterial Colony Counts |
7.096; 6.745; 7.145 | — |
Eligibility Criteria
Intervention Group (vaginal preparation)
Inclusion Criteria
- Pregnant women admitted for cesarean delivery
- Gestational age greater than or equal to 34 weeks
Exclusion Criteria
- Rupture of membranes or active labor
- Chorioamnionitis (prior to enrollment)
- Recent (within 4 weeks) antibiotic exposure
- Maternal HIV infection or immunocompromised state
- Known allergy to shellfish, iodine, or chlorhexidine
Data sourced from ClinicalTrials.gov (NCT03640507) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.