N/A
Completed N=41
Exercise Dosing for Pain in Healthy Participants
Source: ClinicalTrials.gov NCT03642938 ↗Enrolled (actual)
41
Serious AEs
0.0%
Results posted
Aug 2023
Primary outcomePrimary: Intervention Effects on Mechanical Sensitivity Threshold — 125.6; 93.56; 63.04; 70.27 100*Value at 24 hours/Value at Baseline
Summary
In this study investigators will examine the effect of dose related to exercise therapy for pain in healthy adult humans. An acute pain model will be employed to study the effect of exercise dose on pain. Acute pain models are currently used to study pain (both acute and chronic) in human samples as there is currently no chronic pain model.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Intervention Effects on Mechanical Sensitivity Threshold |
125.6; 93.56; 63.04; 70.27; 299; 396.7 | — |
| PRIMARY Intervention Effects on Constant Heat Pain Intensity |
88.79; 80.03; 80.16; 110.4; 59.46; 114.3 | — |
| PRIMARY Intervention Effects on Constant Heat Pain Unpleasantness |
110.1; 130.7; 110.6; 79.63; 65.94; 137.5 | — |
| PRIMARY Intervention Effects on Radiant Heat Sensitivity |
99.08; 101.2; 99.8; 100.8; 100.1; 101.5 | — |
| PRIMARY Intervention Effects on Radiant Heat Pain |
98.65; 96.83; 97.10; 99.2; 100.6; 99.59 | — |
| PRIMARY Intervention Effects on Pressure Pain Threshold |
135.5; 143.3; 150.1; 111; 122.6; 134.7 | — |
| PRIMARY Intervention Effects on Constant Pressure Pain Intensity |
93.3; 49.6; 67.26; 157.6; 89.6; 85.37 | — |
| PRIMARY Intervention Effects on Constant Pressure Pain Unpleasantness |
92.61; 46.62; 46.58; 127.9; 80.51; 76.56 | — |
| SECONDARY Heart Rate |
124.12; 115.87; 112.349; 121.443; 118.8; 110.16 | — |
| SECONDARY Borg Rate of Perceived Exertion (RPE) |
144; 159.4; 152.45; 147.2; 156.3; 161.3 | — |
Eligibility Criteria
Inclusion Criteria
- Between age 18-40
- Normal BMI (18.5-25.0)
- Heart Rate (HR) 60-100 bmp
- BP less than or equal to 140/90
Exclusion Criteria
- Age 40 years
- Cardiac, respiratory, neurological or musculoskeletal disease
- Acute pain
- Chronic pain condition
- Diabetes
- BMI ≥ 25.1 or ≤ 18.4
- Regular participation in high intensity athletic/sporting activities
- Sedentary
- Anxiety or depression disorders
- Tape allergy
- Currently pregnant
Data sourced from ClinicalTrials.gov (NCT03642938). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.