N/A N=41 Randomized Treatment

Exercise Dosing for Pain in Healthy Participants

Pain

Bottom Line

View on ClinicalTrials.gov: NCT03642938 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2023

Primary outcome: Primary: Intervention Effects on Mechanical Sensitivity Threshold — 125.6; 93.56; 63.04; 70.27 100*Value at 24 hours/Value at Baseline

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Walking Exercise (Behavioral); Control (Behavioral)
Age: Adult · 18+ yrs
Sex: All
Sponsor: Duquesne University
Primary completion: Jun 2017

Outcome Measures

Outcome	Result	p-value
PRIMARY Intervention Effects on Mechanical Sensitivity Threshold	125.6; 93.56; 63.04; 70.27; 299; 396.7	—
PRIMARY Intervention Effects on Constant Heat Pain Intensity	88.79; 80.03; 80.16; 110.4; 59.46; 114.3	—
PRIMARY Intervention Effects on Constant Heat Pain Unpleasantness	110.1; 130.7; 110.6; 79.63; 65.94; 137.5	—
PRIMARY Intervention Effects on Radiant Heat Sensitivity	99.08; 101.2; 99.8; 100.8; 100.1; 101.5	—
PRIMARY Intervention Effects on Radiant Heat Pain	98.65; 96.83; 97.10; 99.2; 100.6; 99.59	—
PRIMARY Intervention Effects on Pressure Pain Threshold	135.5; 143.3; 150.1; 111; 122.6; 134.7	—
PRIMARY Intervention Effects on Constant Pressure Pain Intensity	93.3; 49.6; 67.26; 157.6; 89.6; 85.37	—
PRIMARY Intervention Effects on Constant Pressure Pain Unpleasantness	92.61; 46.62; 46.58; 127.9; 80.51; 76.56	—
SECONDARY Heart Rate	124.12; 115.87; 112.349; 121.443; 118.8; 110.16	—
SECONDARY Borg Rate of Perceived Exertion (RPE)	144; 159.4; 152.45; 147.2; 156.3; 161.3	—

Summary

In this study investigators will examine the effect of dose related to exercise therapy for pain in healthy adult humans. An acute pain model will be employed to study the effect of exercise dose on pain. Acute pain models are currently used to study pain (both acute and chronic) in human samples as there is currently no chronic pain model.

Eligibility Criteria

Inclusion Criteria

Between age 18-40
Normal BMI (18.5-25.0)
Heart Rate (HR) 60-100 bmp
BP less than or equal to 140/90

Exclusion Criteria

Age 40 years
Cardiac, respiratory, neurological or musculoskeletal disease
Acute pain
Chronic pain condition
Diabetes
BMI ≥ 25.1 or ≤ 18.4
Regular participation in high intensity athletic/sporting activities
Sedentary
Anxiety or depression disorders
Tape allergy
Currently pregnant

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03642938). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.