N/A
N=5,047
Clinical Decision Support to Implement ED-initiated Buprenorphine for OUD
Clinical Decision Support · Buprenorphine · Opioid-use Disorder
Bottom Line
View on ClinicalTrials.gov: NCT03658642 ↗Enrolled (actual)
5,047
Serious AEs
0.0%
Results posted
Jun 2022
Primary outcome: Primary: Count of Initiating BUP in the ED With Referral for Ongoing MOUD With User-centered CDS Compared With Usual Care — 347; 271 Participants — p=0.58
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Clinical Decision Support (CDS) (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Yale University
- Primary completion
- May 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Count of Initiating BUP in the ED With Referral for Ongoing MOUD With User-centered CDS Compared With Usual Care |
347; 271 | 0.58 |
| SECONDARY Count of Those With Referral to Follow-up for Ongoing MOUD Treatment (Patient Level) |
367; 226 | 0.95 |
| SECONDARY Rates Receiving a MAT Appointment Who go to the Appointment |
— | — |
| SECONDARY Number of Clinicians Providing ED-initiated BUP |
151; 88 | 0.01 sig |
| SECONDARY Number of Clinicians Providing Referral of Any Ongoing MOUD Treatment |
141; 100 | 0.48 |
| SECONDARY Number of Clinicians Who Have Received Drug Addiction Treatment Act (DATA) of 2000 Training |
50; 30 | 0.27 |
Summary
Emergency Departments (EDs) frequently care for individuals with Opioid Use Disorder (OUD). Buprenorphine (BUP) is an effective treatment option for patients with OUD that can safely be initiated in the ED. At present, BUP is rarely initiated as a part of routine ED care. Clinical decision support (CDS) represents a potential approach to accelerate adoption of this best practice into routine emergency care. The goal of this trial is to determine whether implementation of a user-centered clinical decision support (CDS) system can increase adoption of initiation of BUP into the routine emergency care of individuals with OUD.
Eligibility Criteria
Inclusion Criteria
Clinicians
- All clinicians working in Emergency Departments in the selected sites
Patients
- 18 years or older
- Will meet an EHR-derived phenotype suggesting possible OUD will be included in the analysis
- Will be discharged from the ED
- Not pregnant
- Not currently taking any medication for Opioid Use Disorder
Exclusion Criteria
Patients
- Have a medical or psychiatric condition that requires hospitalization during the ED visit
- Have prior enrollment in the current study
- Currently in addiction treatment
- Be a prisoner or in police custody at the time of ED visit
Note: The CDS will also be available for physicians to use when patients do not meet the EHR phenotype. These patients will be excluded from the primary analyses
Data sourced from ClinicalTrials.gov (NCT03658642). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.