Phase 2
Completed N=52
A Methodology Development Environmental Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis
Source: ClinicalTrials.gov NCT03660878 ↗Enrolled (actual)
52
Serious AEs
1.9%
Results posted
Apr 2025
Primary outcomePrimary: Change From Baseline Ocular Itching Score on High Pollen Days — -0.65; 0.16; -0.69 units on a scale
Summary
A Multi-Center, Double-Masked, Randomized, Parallel-Group, Vehicle-Controlled, Methodology Development Environmental Clinical Trial with Reproxalap Ophthalmic Solutions (0.25% and 0.5%) in Subjects with Seasonal Allergic Conjunctivitis.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline Ocular Itching Score on High Pollen Days |
-0.65; 0.16; -0.69 | — |
Eligibility Criteria
Inclusion Criteria
- be at least 18 years of age of either gender and any race
- have a positive history of ocular allergies and a positive skin test reaction to ragweed pollen as confirmed by the allergic skin test given to the subject within 24 months of the subject's Visit 1
- have a calculated visual acuity of 0.7 logMAR or better in each eye as measured using an ETDRS chart
Exclusion Criteria
- have known contraindications or sensitivities to the use of any of the investigational product medication or components
- have any ocular condition that, in the opinion of the investigator, could affect the subject's safety or trial parameters (including but not limited to narrow angle glaucoma, clinically significant blepharitis, follicular conjunctivitis, iritis, pterygium, or a diagnosis of dry eye)
- have had ocular surgical intervention within three months prior to Visit 1, or during the trial, or a history of refractive surgery six months prior to Visit 1, or have systemic surgery planned during the clinical trial or within 30 days after;
- have a known history of retinal detachment, diabetic retinopathy, or active retinal disease
- have an active ocular infection (bacterial, viral or fungal), active uveitis, or positive history of an ocular herpetic infection at any visit;
- be a female who is currently pregnant, planning a pregnancy, or lactating
Data sourced from ClinicalTrials.gov (NCT03660878). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.