N/A
Completed N=64
Weight Loss for Prediabetes Using Episodic Future Thinking
Source: ClinicalTrials.gov NCT03670602 ↗Enrolled (actual)
64
Serious AEs
1.6%
Results posted
Dec 2022
Primary outcomePrimary: Change From Baseline in Delay Discounting — -5.92; -6.11; -3.09; -0.96 ln (k) — p=0.0035
Summary
The goals of the UH3 are to assess the effectiveness of adding Episodic Future Thinking (EFT) to the investigators standard behavioral weight control program to improve weight loss, delay discounting (DD), working memory, glycemic control (HbA1c) and behavioral medication adherence over a 6 month period in persons with prediabetes and comorbid hypertension and/or hyperlipidemia. This will be accomplished by a randomized trial (N = 71 randomized) comparing the effects of EFT versus control that matches attention and use of technology.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline in Delay Discounting |
-5.92; -6.11; -3.09; -0.96; -2.79; -1.33 | 0.0035 sig |
| PRIMARY Change From Baseline in Weight |
102.3; 104.2; -6.8; -7.2; -9.8; -9.8 | 0.85 |
| PRIMARY Change From Baseline in Glycemic Control |
5.90; 5.91; -0.22; -0.27; -0.35; -0.39 | 0.79 |
| SECONDARY Change in Medication Adherence |
84.3; 91.7; 5.33; -0.25; 5.23; 0.09 | 0.201 |
| SECONDARY Changes in Physical Activity |
5.61; 5.67; 1.16; 0.82; 0.91; 0.22 | 0.345 |
| SECONDARY Change in Total Calories |
1802.2; 1886.3; -542.5; -504.7; -298.4; -568.3 | 0.007 sig |
| SECONDARY Changes in Working Memory |
44.6; 46.0; 2.1; 1.6; 6.9; 4.5 | 0.774 |
Eligibility Criteria
Inclusion Criteria
- Overweight or obese (BMI ≥ 25)
- Prediabetes (HbA1c between 5.7 - 6.4%; 39-40 mmol/mol)
Exclusion Criteria
- Type 2 Diabetes
- Use of diabetic drugs
- Pregnancy
- Not ambulatory
- Intellectual impairment
- Unmanaged mood disorders
- Current substance use disorder (excluding nicotine and caffeine)
- History of eating disorders (Except binge eating disorder)
- Abnormal blood glucose related to medications
Data sourced from ClinicalTrials.gov (NCT03670602). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.